GLGA_PROM0
ID GLGA_PROM0 Reviewed; 483 AA.
AC A3PBY3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=P9301_06351;
OS Prochlorococcus marinus (strain MIT 9301).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=167546;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9301;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000576; ABO17258.1; -; Genomic_DNA.
DR RefSeq; WP_011862625.1; NC_009091.1.
DR AlphaFoldDB; A3PBY3; -.
DR SMR; A3PBY3; -.
DR STRING; 167546.P9301_06351; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABO17258; ABO17258; P9301_06351.
DR KEGG; pmg:P9301_06351; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_3; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001430; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..483
FT /note="Glycogen synthase"
FT /id="PRO_1000014373"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 483 AA; 55066 MW; 931BA23CE40BBE62 CRC64;
MRILLAAAEC APMIKVGGMG DVVGSLPPSL IKLGHDVRVI IPGYGKLWSL LDVSNEPVFR
ANTMGTDFSV YEAKHPIHNY VIYLVGHPTF DSDQIYGGEN EDWRFTFFAS ATAEFAWNCW
KPQVLHCHDW HTGMIPVWMH QDPEISTVFT IHNLKYQGPW RWKLEKMTWC PWYMHGDHTM
AAAMLYADRV NAVSPTYADE IKTHEYGESL EGLLNYISGK LRGILNGIDL DEWNPAKDSV
LPAKFSINNL ENRQENKKIL QREMGLEVNP KKYLLGMVSR LVDQKGVDLL LQVSRRLLAY
TDSQIAVLGT GDRYLESGLW QLALDYPGRF SVFLTYDDSL SRLIYGGSDA FLMPSRFEPC
GISQLLAMRY GSIPIVRRVG GLVDTVLPHD PENNSGTGFC FDRFEPIDFY TSLVRSWEAF
RHKDSWKLLQ KRAMSQEFSW QRSALEYEIM YKDVCGIKEP SPDVAEVEKF SYGQSADPSL
KKV
