GLGA_PROM4
ID GLGA_PROM4 Reviewed; 490 AA.
AC A9BAW0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=P9211_10411;
OS Prochlorococcus marinus (strain MIT 9211).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=93059;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9211;
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000878; ABX08972.1; -; Genomic_DNA.
DR RefSeq; WP_012195593.1; NC_009976.1.
DR AlphaFoldDB; A9BAW0; -.
DR SMR; A9BAW0; -.
DR STRING; 93059.P9211_10411; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ABX08972; ABX08972; P9211_10411.
DR KEGG; pmj:P9211_10411; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_3; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000788; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..490
FT /note="Glycogen synthase"
FT /id="PRO_1000126091"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 490 AA; 55352 MW; DC1E0EA18EC32FBF CRC64;
MRVLFAAAEC APMVKVGGMG DVVSSLPPAL AKLGHDVRLI IPGYGKLWSL LDIPSEPIFR
AQAMGSDFAV YETRHPISSL PLYLVGHPAF DPERIYGGDD EDWRFTFFAS ATAEFAWNSW
KPQVLHCHDW HTGMIPVWMH QDPEISTVFT IHNLKYQGPW RWKLERMTWC PWYMQGDHTM
AVAMLYADRV NAVSPTYAKE ICTSEYGEKL DGLLNYISGK LRGILNGIDL DDWNPETDKA
LPANFSASNI LGRRKNKAAL QSQMGLDVKP NSYLLGMVGR LVDQKGVDLL LQVARRLLAY
TDSQIVVLGT GESALESALW QLATEYPGRF AVFLTYDDYL SRLIYAGTDA FLMPSRFEPC
GISQLLAMRY GSIPVVRNVG GLVDTVSPHD PSKQTGTGFC FDRFEPIDFY TALVRSWEAY
RHRRSWRRLQ IRAMTQTYSW DRSAYEYENM YKDVCGVKEP SPDAEEVEKF SVGQDADPSL
KKAVVSDSEK
