GLGA_PSEAE
ID GLGA_PSEAE Reviewed; 513 AA.
AC Q9I1V0;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=PA2165;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; AE004091; AAG05553.1; -; Genomic_DNA.
DR PIR; H83375; H83375.
DR RefSeq; NP_250855.1; NC_002516.2.
DR RefSeq; WP_003115521.1; NZ_QZGE01000014.1.
DR AlphaFoldDB; Q9I1V0; -.
DR SMR; Q9I1V0; -.
DR STRING; 287.DR97_6261; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PaxDb; Q9I1V0; -.
DR PRIDE; Q9I1V0; -.
DR EnsemblBacteria; AAG05553; AAG05553; PA2165.
DR GeneID; 881026; -.
DR KEGG; pae:PA2165; -.
DR PATRIC; fig|208964.12.peg.2265; -.
DR PseudoCAP; PA2165; -.
DR HOGENOM; CLU_009583_18_4_6; -.
DR InParanoid; Q9I1V0; -.
DR OMA; TWCPWYM; -.
DR PhylomeDB; Q9I1V0; -.
DR BioCyc; PAER208964:G1FZ6-2205-MON; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..513
FT /note="Glycogen synthase"
FT /id="PRO_0000188632"
FT BINDING 47
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 513 AA; 56562 MW; 66585F86FAA8AB9C CRC64;
MGHSVAGVCL EEPAVLTAFP SLLHPQDPPQ QRDRILFVTA ELSDFVKVGG LGDFSAALPR
VLKREHSVRV LLPGYRQVLE RCRDLRIIGS LPGRAAIPPC EIGLVTLDDG LEVMLVLCPL
LYEREGTPYM DDQGNDWPDN HLRFARLCLA AAEIAGGRGA QGWQPGLVHA NDWPSALTPA
YMAWNGVRTP SLFTIHNLAY QGLCDLQCSA ELGLPDEALS HESMEFHGRL SFLKAGIAHA
HHITTVSETY AQEITTPEYG CGLHGILKYK VEKRQLSGIV NGIDDSWQPH CDPHLVACFS
ARQWAGKRAN TRYVEERFGL EPGKGPLFAV VSRLVQQKGI DLTLEISDAL LQAGGRLVSI
GRGEPNLEKA MLELARRHPG QVGVHIGFDE TEARRIYAGS DFLLMPSRYE PCGLSQLYAQ
CFGSLPIARC TGGLADTIVD GVTGFLFREE TAQSYLDAVM RAINVYHCPS LLNAMRCKAM
AAPMFWSDSV EPYNRLYRRL LRNTAPALRG VRQ