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GLGA_STRSV
ID   GLGA_STRSV              Reviewed;         476 AA.
AC   A3CM04;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=SSA_0778;
OS   Streptococcus sanguinis (strain SK36).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=388919;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SK36;
RX   PubMed=17277061; DOI=10.1128/jb.01808-06;
RA   Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA   Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA   Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT   "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL   J. Bacteriol. 189:3166-3175(2007).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; CP000387; ABN44209.1; -; Genomic_DNA.
DR   RefSeq; WP_011836716.1; NC_009009.1.
DR   RefSeq; YP_001034759.1; NC_009009.1.
DR   AlphaFoldDB; A3CM04; -.
DR   SMR; A3CM04; -.
DR   STRING; 388919.SSA_0778; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PRIDE; A3CM04; -.
DR   EnsemblBacteria; ABN44209; ABN44209; SSA_0778.
DR   KEGG; ssa:SSA_0778; -.
DR   PATRIC; fig|388919.9.peg.744; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_9; -.
DR   OMA; TWCPWYM; -.
DR   OrthoDB; 83240at2; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000002148; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..476
FT                   /note="Glycogen synthase"
FT                   /id="PRO_1000014385"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   476 AA;  54265 MW;  143EC5F314826406 CRC64;
     MKILFAAAEG APFSKTGGLG DVIGALPKSL VKAGHEVGVI LPYYDMTHAK FGDQVEDLFY
     FEVSVGWRRQ YVGVKRLVLN GVSFYFIDNQ HYFFRGHVYG DFDDGERFAY FQLAAVELME
     RIDFIPDVLH VHDYHTAMIP FLVKEKYHWI QAYQNITTVL TIHNLEFQGQ FPDSMLWELF
     GVGYERYADG TLRWNDCLNW MKAGILYADR VTTVSPSYAS EIRTPEFGCN LDQILRMESG
     KLVGIVNGID TDIYNPETDP LLAHHFDKSD LSGKLENKRA LQERVGLPVR DDVPVVGIVS
     RLTRQKGFDL VVEELHNLLQ EDVQIILLGT GDPAFEQAFA WFGHAYPDKL SANILFDVTL
     AQEIYAASDI FLMPSRFEPC GLSQMMAMRY GTLPLVHEVG GLRDTVEPYN VYTGKGTGFS
     FNNFSGYWLT WTFKEALKLY ADDKEAWKSL QEQAMERDFS WDTASKAYSD LYQSLL
 
 
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