GLGA_STRSV
ID GLGA_STRSV Reviewed; 476 AA.
AC A3CM04;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=SSA_0778;
OS Streptococcus sanguinis (strain SK36).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=388919;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK36;
RX PubMed=17277061; DOI=10.1128/jb.01808-06;
RA Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL J. Bacteriol. 189:3166-3175(2007).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000387; ABN44209.1; -; Genomic_DNA.
DR RefSeq; WP_011836716.1; NC_009009.1.
DR RefSeq; YP_001034759.1; NC_009009.1.
DR AlphaFoldDB; A3CM04; -.
DR SMR; A3CM04; -.
DR STRING; 388919.SSA_0778; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; A3CM04; -.
DR EnsemblBacteria; ABN44209; ABN44209; SSA_0778.
DR KEGG; ssa:SSA_0778; -.
DR PATRIC; fig|388919.9.peg.744; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_9; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002148; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..476
FT /note="Glycogen synthase"
FT /id="PRO_1000014385"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 476 AA; 54265 MW; 143EC5F314826406 CRC64;
MKILFAAAEG APFSKTGGLG DVIGALPKSL VKAGHEVGVI LPYYDMTHAK FGDQVEDLFY
FEVSVGWRRQ YVGVKRLVLN GVSFYFIDNQ HYFFRGHVYG DFDDGERFAY FQLAAVELME
RIDFIPDVLH VHDYHTAMIP FLVKEKYHWI QAYQNITTVL TIHNLEFQGQ FPDSMLWELF
GVGYERYADG TLRWNDCLNW MKAGILYADR VTTVSPSYAS EIRTPEFGCN LDQILRMESG
KLVGIVNGID TDIYNPETDP LLAHHFDKSD LSGKLENKRA LQERVGLPVR DDVPVVGIVS
RLTRQKGFDL VVEELHNLLQ EDVQIILLGT GDPAFEQAFA WFGHAYPDKL SANILFDVTL
AQEIYAASDI FLMPSRFEPC GLSQMMAMRY GTLPLVHEVG GLRDTVEPYN VYTGKGTGFS
FNNFSGYWLT WTFKEALKLY ADDKEAWKSL QEQAMERDFS WDTASKAYSD LYQSLL