GLGA_THEAB
ID GLGA_THEAB Reviewed; 485 AA.
AC B7IFD0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=THA_294;
OS Thermosipho africanus (strain TCF52B).
OC Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX NCBI_TaxID=484019;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TCF52B;
RX PubMed=19124572; DOI=10.1128/jb.01448-08;
RA Nesboe C.L., Bapteste E., Curtis B., Dahle H., Lopez P., Macleod D.,
RA Dlutek M., Bowman S., Zhaxybayeva O., Birkeland N.-K., Doolittle W.F.;
RT "The genome of Thermosipho africanus TCF52B: lateral genetic connections to
RT the Firmicutes and Archaea.";
RL J. Bacteriol. 191:1974-1978(2009).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001185; ACJ74794.1; -; Genomic_DNA.
DR RefSeq; WP_012579478.1; NC_011653.1.
DR AlphaFoldDB; B7IFD0; -.
DR SMR; B7IFD0; -.
DR STRING; 484019.THA_294; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; B7IFD0; -.
DR EnsemblBacteria; ACJ74794; ACJ74794; THA_294.
DR KEGG; taf:THA_294; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_0; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002453; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..485
FT /note="Glycogen synthase"
FT /id="PRO_1000126108"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 485 AA; 55785 MW; 22D43DA6A5F7FA6F CRC64;
MKVALVSYEV YPFAKVGGLA DVVGALPKYL KNFSVEPIVI MPKHKIVEKN AEKFSYSLRK
IKESISVPYL KTDEKFDIYQ TFIPGTQIPV YLIANDYYFS AEQVYEGPDL AEQAIYFSAA
VFEALKVLGE KVDVLHINDW QTGLVPVYLK TLYKDDEFFS KTVVLLTIHN LGYQGIFDSS
YMNFSGLPDY LYNIDGIEFY GKINFLKGGI LFSDVINTVS PTYAQEIQTK EYGEKLDGVL
RLRSSDLYGI LNGIDYDEYN PETDKRIYVN YSLQEIEKKY ENKKMLQKEL NLPQTNDVPV
IGMITRLVDQ KGLDILSEVL RYILNMDVQF VLLGTGDKKY EEMFKDIEKE FPDKMSANIT
FDIVLAQKIY ASSDMFLMPS RYEPCGLGQM YSLRYGTIPV VRYTGGLADT VMEYDEEAMK
GNGFGFKEYD SAYLLKAVAR AVDFFKNKKG HWKKLIENAM KTDLSWERSA NEYVKIYNKA
LNKRR
