ID   GLGA_THECA              Reviewed;         438 AA.
AC   P58395;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484};
OS   Thermus caldophilus.
OC   Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX   NCBI_TaxID=272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GK24;
RA   Kim M., Ko J.H., Jung B.W., Kim J.S., Lee D.-S.;
RT   "Molecular cloning and expression of Thermus caldophilus glycogen synthase
RT   gene.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; AF289823; AAK60012.1; -; Genomic_DNA.
DR   AlphaFoldDB; P58395; -.
DR   SMR; P58395; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PRIDE; P58395; -.
DR   UniPathway; UPA00164; -.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT   CHAIN           1..438
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188657"
FT   BINDING         16
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   438 AA;  48498 MW;  D756EEDCBD9256BB CRC64;
     MIRVLHLAPE AYPLAKVGGL ADVVGALPKA LRPLGVEAHV LLPWHGGLEA RRVGEVAFAF
     FGREERAPLG ERVEGGVRFL LLGVEGFGRE RVYGYPDDAE RYLRFALAAK EVARGYDLVH
     AHDWTAALLA LYAPTVYTIH NLAHQGLVDP GLFFSWTGLP WSLFHMEALE FYGRVNLMKG
     GIVFARRVTT VRPSYAEEIQ TPEFGMGLDG VLRRHAGKLR GILNGLDTEV FDPGKDPYLP
     APYTREDPSG KARAKEVFRE RTGLRPPVLA YVGRLDYQKG LDLVLKALPR LLEMGFRLYV
     QGVGDGGLQE AFLRAEEENP EGVRFLPAYD EAMARLAYAG AEAVLVPSRF EPCGLVQMIA
     SRYGTPPVAR AVGGLKDTVE DGRAGVLFET YHPEGLLYGV LRLFRLGAEE MGLRAMEKDF
     SWEGPARAYR EVYREALG