GLGA_THEM4
ID GLGA_THEM4 Reviewed; 481 AA.
AC A6LJ53;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Tmel_0077;
OS Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429).
OC Bacteria; Thermotogae; Thermotogales; Fervidobacteriaceae; Thermosipho.
OX NCBI_TaxID=391009;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12029 / CIP 104789 / BI429;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT "Complete sequence of Thermosipho melanesiensis BI429.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000716; ABR29954.1; -; Genomic_DNA.
DR RefSeq; WP_012056316.1; NC_009616.1.
DR AlphaFoldDB; A6LJ53; -.
DR SMR; A6LJ53; -.
DR STRING; 391009.Tmel_0077; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; A6LJ53; -.
DR EnsemblBacteria; ABR29954; ABR29954; Tmel_0077.
DR KEGG; tme:Tmel_0077; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_0; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001110; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..481
FT /note="Glycogen synthase"
FT /id="PRO_1000014389"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 481 AA; 55404 MW; 7DFB61188071338B CRC64;
MKVALISYEV YPFAKVGGLA DVVGALPKYL EKASVKPIVI MPKHKVVEKN ARNLDKVMEK
ISIPYLKTDE TFDIYKTIVP KTNVPIYFVA NEYYFSAENV YEGPDLAEQA IYFSAAVLET
LKVLDLQMDV LHVNDWQTSL IPVYLKTLYK EDEFYAKTVT LLTIHNLGYQ GIFDSKYMEF
SGLPNYLYNI DGIEFYGKIN FLKGGILYSD IINTVSPTYA NEIQTKEYGE KLDGVLRLRS
ADLYGVLNGI DYDEYNPETD KRIFVNYSLD NIDKKYENKV RLQKELGLPE DRRIPMIGMI
TRLVDQKGLD ILSEVLRYIV NYDIQFVILG TGDEKYEEMF KKAQQEFPKN VSANVKFDIN
LAQKIYAASD MFLMPSRYEP CGLGQMYSLR YGTIPIVRYT GGLADTVLEY DENKMTGNGF
GFVEYDSSKL LKAVARALDF YKNKKVHWKK LIDNAMKTDL SWERSAKEYV KLYNKAMSKR
I
