ID   GLGA_THEP1              Reviewed;         486 AA.
AC   A5IIN8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Tpet_0032;
OS   Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 /
OS   RKU-1).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=390874;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA   Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C.,
RA   Tapia R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.;
RT   "Complete sequence of Thermotoga petrophila RKU-1.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; CP000702; ABQ46061.1; -; Genomic_DNA.
DR   RefSeq; WP_011942738.1; NC_009486.1.
DR   AlphaFoldDB; A5IIN8; -.
DR   SMR; A5IIN8; -.
DR   STRING; 390874.Tpet_0032; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PRIDE; A5IIN8; -.
DR   EnsemblBacteria; ABQ46061; ABQ46061; Tpet_0032.
DR   KEGG; tpt:Tpet_0032; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_0; -.
DR   OMA; TWCPWYM; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000006558; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT   CHAIN           1..486
FT                   /note="Glycogen synthase"
FT                   /id="PRO_1000014390"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   486 AA;  55554 MW;  33475F59C4F669BF CRC64;
     MKVVFVSYEV FPFAKVGGLA DVAGTLPKYL KKHGVDVTIV MPKHRIVEKN AEKFGYEIKK
     VAEGLSVSHV KTDQKFDIYE SVLPGSDVKT YFVANDYYFS AEDVYAGPDL GEQAIFFCAA
     TLDLVKHLDL KPDIVHVNDW QTALIPVYLK TVYRDDPYFS RTATVLTIHN LGYQGVFDPK
     YLSFAGLPDY VFTIDGLEFY RQLNFLKGGI VFSDVINTVS PTYAEEIQTE EYGEKLEGVL
     RMRSKDLYGI LNGIDYELYN PATDRYIYVN YDVNRLELKW ENKVKLQEEL GLPVNKETAV
     AGLISRLVPQ KGLDLLVDVM DYLMLFDLQI VVLGTGDEQY ENAFRKFQER YPDKVSANIK
     FDVELAQKIY AGADIFLMPS RYEPCGLGQM FSMRYGTIPV VRYTGGLADT VKEYDPQSME
     GTGFGFKKYD SAHLLKAVSK ALHFYYREKD HWRRIMTNAM NTDLSWDRSA KEYVDLYKKA
     LAKVGR