GLGA_THESQ
ID GLGA_THESQ Reviewed; 486 AA.
AC B1LC39;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=TRQ2_0032;
OS Thermotoga sp. (strain RQ2).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga;
OC unclassified Thermotoga.
OX NCBI_TaxID=126740;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RQ2;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Bruce D.B., Goodwin L., Pitluck S., Saunders E., Brettin T.,
RA Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K.,
RA Richardson P.;
RT "Complete sequence of Thermotoga sp. RQ2.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000969; ACB08394.1; -; Genomic_DNA.
DR RefSeq; WP_011942738.1; NC_010483.1.
DR AlphaFoldDB; B1LC39; -.
DR SMR; B1LC39; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACB08394; ACB08394; TRQ2_0032.
DR KEGG; trq:TRQ2_0032; -.
DR HOGENOM; CLU_009583_18_2_0; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001687; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..486
FT /note="Glycogen synthase"
FT /id="PRO_1000126109"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 486 AA; 55554 MW; 33475F59C4F669BF CRC64;
MKVVFVSYEV FPFAKVGGLA DVAGTLPKYL KKHGVDVTIV MPKHRIVEKN AEKFGYEIKK
VAEGLSVSHV KTDQKFDIYE SVLPGSDVKT YFVANDYYFS AEDVYAGPDL GEQAIFFCAA
TLDLVKHLDL KPDIVHVNDW QTALIPVYLK TVYRDDPYFS RTATVLTIHN LGYQGVFDPK
YLSFAGLPDY VFTIDGLEFY RQLNFLKGGI VFSDVINTVS PTYAEEIQTE EYGEKLEGVL
RMRSKDLYGI LNGIDYELYN PATDRYIYVN YDVNRLELKW ENKVKLQEEL GLPVNKETAV
AGLISRLVPQ KGLDLLVDVM DYLMLFDLQI VVLGTGDEQY ENAFRKFQER YPDKVSANIK
FDVELAQKIY AGADIFLMPS RYEPCGLGQM FSMRYGTIPV VRYTGGLADT VKEYDPQSME
GTGFGFKKYD SAHLLKAVSK ALHFYYREKD HWRRIMTNAM NTDLSWDRSA KEYVDLYKKA
LAKVGR
