GLGA_THET2
ID GLGA_THET2 Reviewed; 437 AA.
AC Q72G68;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=TT_C1980;
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS82322.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE017221; AAS82322.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q72G68; -.
DR SMR; Q72G68; -.
DR STRING; 262724.TT_C1980; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; AAS82322; AAS82322; TT_C1980.
DR KEGG; tth:TT_C1980; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_5_0; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000592; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..437
FT /note="Glycogen synthase"
FT /id="PRO_0000230267"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 437 AA; 48174 MW; B2C52E0E6745B843 CRC64;
MRVLHVAPEA YPLAKVGGLA DVVGALPKAL GPLGVEAHVL LPWHGGLEAR RVGEVAFAFF
GREERAPLGE RVEGGVRFLL LGVEGFGRER VYGYPDDAER YLRFALAAKE VARGYDLVHA
HDWTAALLAL YAPTVYTIHN LAHQGLVDPG LFFSWTGLPW SLFHMEALEF YGRVNLMKGG
IVFARRVTTV SPSYAEEIQT PEFGMGLDGV LRRHAGKLRG ILNGLDTEVF DPGKDPYLPA
PYTREDPSGK ARAKEAFRER TGLRPPVLAY VGRLDYQKGL DLVLKALPRL LEMGFRLYVQ
GVGDGGLQEA FLRAEEENPE GVRFLPAYDE AMARLAYAGA EAVLVPSRFE PCGLVQMIAS
RYGTPPVARA VGGLKDTVED GRAGVLFETY HPEGLLYGVL RLFRLGAEEM GLRAMEKDFS
WEGPARAYRE VYREALG
