GLGA_THET8
ID GLGA_THET8 Reviewed; 437 AA.
AC Q5SMC5;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=TTHA0018;
OS Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=300852;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27634 / DSM 579 / HB8;
RA Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T.,
RA Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S.;
RT "Complete genome sequence of Thermus thermophilus HB8.";
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD69841.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AP008226; BAD69841.1; ALT_INIT; Genomic_DNA.
DR RefSeq; YP_143284.1; NC_006461.1.
DR AlphaFoldDB; Q5SMC5; -.
DR SMR; Q5SMC5; -.
DR STRING; 300852.55771400; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; BAD69841; BAD69841; BAD69841.
DR KEGG; ttj:TTHA0018; -.
DR PATRIC; fig|300852.9.peg.19; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_5_0; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000000532; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..437
FT /note="Glycogen synthase"
FT /id="PRO_0000230268"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 437 AA; 48259 MW; 255F032F2EE26452 CRC64;
MRVLHVAPEA YPLAKVGGLA DVVGALPKAL RPLGVEAHVL LPWHGGLEAR RVGEVAFAFF
GREERAPLGE RVEGGVRFLL LGVEGFGRER VYGYPDDAER YLRFALAAKE VARGYDLVHA
HDWTAALLAL YAPTVYTIHN LAHQGLVDPG LFFSWTGLPW SLFHMEALEF YGRVNLMKGG
IVFARRVTTV SPSYAEEIQT PEFGMGLDGV LRRHAGKLRG ILNGLDTEVF DPGKDPYLPA
PYTREDPSGK ARAKEAFRER TGLRPPVLAY VGRLDYQKGL DLVLKALPRL LEMGFRLYVQ
GVGDGGLQEA FLRAEEENPE GVRFLPAYDE AMARLAYAGA EAVLVPSRFE PCGLVQMIAS
RYGTPPVARA VGGLKDTVED GRGGVLFETY HPEGLLYGVL RLFRLGAEEM GLRAMEKDFS
WEGPARAYRE VYREALG
