GLGA_THIDA
ID GLGA_THIDA Reviewed; 493 AA.
AC Q3SH79;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Tbd_2057;
OS Thiobacillus denitrificans (strain ATCC 25259).
OC Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC Thiobacillaceae; Thiobacillus.
OX NCBI_TaxID=292415;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25259;
RX PubMed=16452431; DOI=10.1128/jb.188.4.1473-1488.2006;
RA Beller H.R., Chain P.S., Letain T.E., Chakicherla A., Larimer F.W.,
RA Richardson P.M., Coleman M.A., Wood A.P., Kelly D.P.;
RT "The genome sequence of the obligately chemolithoautotrophic, facultatively
RT anaerobic bacterium Thiobacillus denitrificans.";
RL J. Bacteriol. 188:1473-1488(2006).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAZ98010.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000116; AAZ98010.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_041432692.1; NC_007404.1.
DR AlphaFoldDB; Q3SH79; -.
DR SMR; Q3SH79; -.
DR STRING; 292415.Tbd_2057; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; AAZ98010; AAZ98010; Tbd_2057.
DR KEGG; tbd:Tbd_2057; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_4_4; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000008291; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..493
FT /note="Glycogen synthase"
FT /id="PRO_0000230269"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 493 AA; 54401 MW; 066D5448E75CEADA CRC64;
MKVLFVASEA FPLVKTGGLG DVLHGLPQAL HGLGVGVRLL LPGYRTLLRQ LDQVRIVAWF
DVRGAEGPVA ARVLETRHPG FDFPLWIVDC PPLFDRPGNP YVDVTGYDWP DNAERFAVFA
RVAALLAQDA HEAGWLPDVV HTHDWQTGLV PAFLADLPAR PRTVFTIHNL AYGGHFPHGD
FLRLQLPAHW WSHEGVEFHG GFSMLKAGIV YADAVTTVSP TYAEEICTPA FGYGLDGLLR
SRRHKLHGIL NGIDSATWDP ADDPHLRARY TAGRILPGKR RDKQALLERF LPAADEAALQ
APLVGLVGRL VEQKGIDWVL AAMPLLLAET DARFVLLGSG QAAYEQRLTR LARQHPTRVF
VEIGYDEALA HQIEAGADMF LMPSRFEPCG LNQMYSLRYG TLPIVFKTGG LADTIVDTNE
ASLADGSANG FVFDTPDVAH FVDAVRRALA LYRQPSLWRR VQQTGMRLSF DWRESAGHYL
ALYAADSAGE PDV
