GLGA_THISH
ID GLGA_THISH Reviewed; 483 AA.
AC B8GNA4;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Tgr7_0874;
OS Thioalkalivibrio sulfidiphilus (strain HL-EbGR7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Thioalkalivibrio.
OX NCBI_TaxID=396588;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HL-EbGR7;
RX PubMed=21475584; DOI=10.4056/sigs.1483693;
RA Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Clum A., Ivanova N.,
RA Pati A., d'Haeseleer P., Woyke T., Kyrpides N.C.;
RT "Complete genome sequence of 'Thioalkalivibrio sulfidophilus' HL-EbGr7.";
RL Stand. Genomic Sci. 4:23-35(2011).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001339; ACL71965.1; -; Genomic_DNA.
DR RefSeq; WP_012637453.1; NC_011901.1.
DR AlphaFoldDB; B8GNA4; -.
DR SMR; B8GNA4; -.
DR STRING; 396588.Tgr7_0874; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACL71965; ACL71965; Tgr7_0874.
DR KEGG; tgr:Tgr7_0874; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_5_6; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002383; Chromosome.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..483
FT /note="Glycogen synthase"
FT /id="PRO_1000190090"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 483 AA; 52854 MW; DBAC73728CB03BAC CRC64;
MRILFASSEV HPLIKTGGLA DVSASLPQAL KRLRQDVRVV MPAYGSVLDK AGDLEQVTTL
QLPGFPGDTV TLLSGTLPGS RVPLWLVDAP RLFRRAGDPY RAPDGHDWQD NYLRFGLFAR
LIEHLALDRA GLDWRPDVVH CNDWQAGLAP LMLSMHESRP ATVFTIHNLA YQGLFPRHAF
DALNLPPQLW HYQGLEFHGK LSFIKGGIGF ADHITTVSPS YAREILTPQQ GFGLDGLLNH
RAGVLTGILN GVDYREWDPG KDRHLVARYS ADDLSGKARC KAALQHHFKL PCHSGIPLLG
HVGRMVAQKG VDLLLKAAEP LLAAGEAQLV VVGSGDATLE QTARSLAERY PEHMGLHIGY
SEPLAHQLEA GADIFVMPSR FEPCGLNQMY SLRYGTVPVV RNTGGLADTV VDADPAHLAA
RDATGIQFDE ATPQALADAL ARALALYHDP ACWKRLMQAG MAQDFSWGRS AEAYLDLYKD
LVS
