GLGA_VARPS
ID GLGA_VARPS Reviewed; 495 AA.
AC C5CJ75;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=Vapar_0412;
OS Variovorax paradoxus (strain S110).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Variovorax.
OX NCBI_TaxID=543728;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S110;
RX PubMed=21183664; DOI=10.1128/jb.00925-10;
RA Han J.I., Choi H.K., Lee S.W., Orwin P.M., Kim J., Laroe S.L., Kim T.G.,
RA O'Neil J., Leadbetter J.R., Lee S.Y., Hur C.G., Spain J.C.,
RA Ovchinnikova G., Goodwin L., Han C.;
RT "Complete genome sequence of the metabolically versatile plant growth-
RT promoting endophyte, Variovorax paradoxus S110.";
RL J. Bacteriol. 193:1183-1190(2011).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001635; ACS17075.1; -; Genomic_DNA.
DR RefSeq; WP_012745575.1; NC_012791.1.
DR AlphaFoldDB; C5CJ75; -.
DR SMR; C5CJ75; -.
DR STRING; 543728.Vapar_0412; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR PRIDE; C5CJ75; -.
DR EnsemblBacteria; ACS17075; ACS17075; Vapar_0412.
DR GeneID; 45054742; -.
DR KEGG; vap:Vapar_0412; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_4_4; -.
DR OMA; TWCPWYM; -.
DR OrthoDB; 83240at2; -.
DR UniPathway; UPA00164; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..495
FT /note="Glycogen synthase"
FT /id="PRO_1000206435"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 495 AA; 53194 MW; 546E148BFFB81217 CRC64;
MRILQVSAEL FPLLKTGGLA DVAGALPLAL MAAGQDARVL LPGFPAILAG VRELAPVAEF
TAPWGPERFG LRAGRIAIDG AAAPITAYVI DAPVLYDRPG NPYEDATRQP YGDNHRRFAL
LGWAAAQLAQ GLDPAWQPEV VHAHDWHAGL APAYLHFARE AGLTRTGSVF TVHNLAYQGI
SAPWNFADLG LPAPAFHMNG LEYHGQVSFM KGGLYFADRL TTVSPTYARE IQTPEQGFGL
DGLLRLRGGV LTGILNAVDD EVWNPATDSA LVQGYHTPDG RHMAGKARCK AVLQHQLGLA
ERPDAPLFIL VSRLTEQKGL HLVLGGLDTL LAEGGQLALL GSGEAGLEQA FRERAAAAPR
AVSVTIGYNE TLAHQLFGGG DVTLVPSLFE PCGLTQMYGL KYGSLPLVRR VGGLADTVVD
CTLEDMASGH ATGFVFDRFD AADYDRALRR AFALYQRAPD WRRVRGNAMR RPADWASAAG
QYIEVYRQAL ESAGT
