ID   GLGA_VIBC3              Reviewed;         484 AA.
AC   A5F7G0; C3M1C4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484};
GN   OrderedLocusNames=VC0395_A1329, VC395_1843;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
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DR   EMBL; CP000627; ABQ19573.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP09840.1; -; Genomic_DNA.
DR   RefSeq; WP_000434699.1; NZ_JAACZH010000016.1.
DR   AlphaFoldDB; A5F7G0; -.
DR   SMR; A5F7G0; -.
DR   STRING; 345073.VC395_1843; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   EnsemblBacteria; ABQ19573; ABQ19573; VC0395_A1329.
DR   GeneID; 57740378; -.
DR   KEGG; vco:VC0395_A1329; -.
DR   KEGG; vcr:VC395_1843; -.
DR   PATRIC; fig|345073.21.peg.1786; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_6; -.
DR   OMA; CGWVHGR; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT   CHAIN           1..484
FT                   /note="Glycogen synthase"
FT                   /id="PRO_1000072416"
FT   BINDING         18
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   484 AA;  55067 MW;  776D1D3E6BCC0920 CRC64;
     MEQFNVWFTV SEVQGLVKSG GLADVAKALP QALKALHQQV AIALPAYRSV PGKEDAELVL
     ETELTHWPHT QYRVLKRDLD GVPIYLIDCP AYFDRPALYA ENNQAYADNG ERFGFFSAAC
     LDVLPKLGIQ PDIIHANDWH TGLVPFLLKT RYRYDSFFEQ VKSVLTVHNA IFKGIFSYHQ
     LEVIPELNLS GMEFLQYGHD HVSMLRAGIA FADKVNAVSP NYAAELLTPL GAHGLVDDFV
     RRARDLHGIV NGCDYSEWNP RTDHYLPATY SDEPESMRKG KALCKTALQE ELHLPVTDVP
     LFGMVCRLTH QKGFHYLLPI LEQFLRNNVQ VVIVGTGEPE VAARLNKIAH YHRAKFAFVE
     TYSERLAHWV EAGSDFFLMP SEFEACGLNQ IYSMAYGTLP IVREVGGLKD TVNDYDKFPE
     RATGFGYQEP TPEALLITMQ RALLFYLQQP EEMLKVQQRA MQQNFSWEES AQEYMKMYRL
     ARFG