ID   GLGA_VIBCH              Reviewed;         484 AA.
AC   Q9KRB6;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE            EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE   AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN   Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=VC_1726;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00484}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC       Rule:MF_00484}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE003852; AAF94876.1; -; Genomic_DNA.
DR   PIR; F82165; F82165.
DR   RefSeq; NP_231362.1; NC_002505.1.
DR   RefSeq; WP_000434699.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KRB6; -.
DR   SMR; Q9KRB6; -.
DR   STRING; 243277.VC_1726; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   DNASU; 2613731; -.
DR   EnsemblBacteria; AAF94876; AAF94876; VC_1726.
DR   GeneID; 57740378; -.
DR   KEGG; vch:VC_1726; -.
DR   PATRIC; fig|243277.26.peg.1652; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_2_6; -.
DR   OMA; CGWVHGR; -.
DR   BioCyc; VCHO:VC1726-MON; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IBA:GO_Central.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   TIGRFAMs; TIGR02095; glgA; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..484
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188660"
FT   BINDING         18
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ   SEQUENCE   484 AA;  55067 MW;  776D1D3E6BCC0920 CRC64;
     MEQFNVWFTV SEVQGLVKSG GLADVAKALP QALKALHQQV AIALPAYRSV PGKEDAELVL
     ETELTHWPHT QYRVLKRDLD GVPIYLIDCP AYFDRPALYA ENNQAYADNG ERFGFFSAAC
     LDVLPKLGIQ PDIIHANDWH TGLVPFLLKT RYRYDSFFEQ VKSVLTVHNA IFKGIFSYHQ
     LEVIPELNLS GMEFLQYGHD HVSMLRAGIA FADKVNAVSP NYAAELLTPL GAHGLVDDFV
     RRARDLHGIV NGCDYSEWNP RTDHYLPATY SDEPESMRKG KALCKTALQE ELHLPVTDVP
     LFGMVCRLTH QKGFHYLLPI LEQFLRNNVQ VVIVGTGEPE VAARLNKIAH YHRAKFAFVE
     TYSERLAHWV EAGSDFFLMP SEFEACGLNQ IYSMAYGTLP IVREVGGLKD TVNDYDKFPE
     RATGFGYQEP TPEALLITMQ RALLFYLQQP EEMLKVQQRA MQQNFSWEES AQEYMKMYRL
     ARFG