GLGA_VIBCM
ID GLGA_VIBCM Reviewed; 484 AA.
AC C3LN49;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=VCM66_1666;
OS Vibrio cholerae serotype O1 (strain M66-2).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=579112;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M66-2;
RX PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA Wang W., Wang J., Qian W., Li D., Wang L.;
RT "A recalibrated molecular clock and independent origins for the cholera
RT pandemic clones.";
RL PLoS ONE 3:E4053-E4053(2008).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP001233; ACP05975.1; -; Genomic_DNA.
DR RefSeq; WP_000434699.1; NC_012578.1.
DR AlphaFoldDB; C3LN49; -.
DR SMR; C3LN49; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; ACP05975; ACP05975; VCM66_1666.
DR GeneID; 57740378; -.
DR KEGG; vcm:VCM66_1666; -.
DR HOGENOM; CLU_009583_18_2_6; -.
DR OMA; CGWVHGR; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000001217; Chromosome I.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..484
FT /note="Glycogen synthase"
FT /id="PRO_1000190091"
FT BINDING 18
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 484 AA; 55067 MW; 776D1D3E6BCC0920 CRC64;
MEQFNVWFTV SEVQGLVKSG GLADVAKALP QALKALHQQV AIALPAYRSV PGKEDAELVL
ETELTHWPHT QYRVLKRDLD GVPIYLIDCP AYFDRPALYA ENNQAYADNG ERFGFFSAAC
LDVLPKLGIQ PDIIHANDWH TGLVPFLLKT RYRYDSFFEQ VKSVLTVHNA IFKGIFSYHQ
LEVIPELNLS GMEFLQYGHD HVSMLRAGIA FADKVNAVSP NYAAELLTPL GAHGLVDDFV
RRARDLHGIV NGCDYSEWNP RTDHYLPATY SDEPESMRKG KALCKTALQE ELHLPVTDVP
LFGMVCRLTH QKGFHYLLPI LEQFLRNNVQ VVIVGTGEPE VAARLNKIAH YHRAKFAFVE
TYSERLAHWV EAGSDFFLMP SEFEACGLNQ IYSMAYGTLP IVREVGGLKD TVNDYDKFPE
RATGFGYQEP TPEALLITMQ RALLFYLQQP EEMLKVQQRA MQQNFSWEES AQEYMKMYRL
ARFG
