GLGA_VIBVY
ID GLGA_VIBVY Reviewed; 485 AA.
AC Q7MJ50;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484}; OrderedLocusNames=VV2312;
OS Vibrio vulnificus (strain YJ016).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=196600;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YJ016;
RX PubMed=14656965; DOI=10.1101/gr.1295503;
RA Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA Lee C.-T., Hor L.-I., Tsai S.-F.;
RT "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL Genome Res. 13:2577-2587(2003).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC95076.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BA000037; BAC95076.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q7MJ50; -.
DR SMR; Q7MJ50; -.
DR STRING; 672.VV93_v1c20220; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR EnsemblBacteria; BAC95076; BAC95076; BAC95076.
DR KEGG; vvy:VV2312; -.
DR eggNOG; COG0297; Bacteria.
DR HOGENOM; CLU_009583_18_2_6; -.
DR OMA; CGWVHGR; -.
DR UniPathway; UPA00164; -.
DR Proteomes; UP000002675; Chromosome I.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW Transferase.
FT CHAIN 1..485
FT /note="Glycogen synthase"
FT /id="PRO_0000188663"
FT BINDING 20
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 485 AA; 54229 MW; 05428836D7237D6D CRC64;
MATNPLSILF VASEVEGLIK SGGLADVAKA LPEALVNLQH DARIAIPAYT AIPNVCDDEV
ILDTHLETWP HTHYQVKKRF LGDNPVYLIA CGHYFDRPSM YAENNQAYTD NGERFAFFSA
ACLDMLPKIG FQPDIVHAND WHTGLVPFLL KHRYGQDPFF AQTKSILSIH NAVFKGVFHY
DEMQCLPEFH CRNVPDAAVS STHMTMLKAG VMNADKINAV SPTYAEELKT ELGSHGMAWE
FQQRAGDLVG ILNGCDYSAW HPDTDSYLPI NYKATKQSMV RGKNGCKRAL QEQVGLPVKD
VAMFGMVCRL THQKGVHYLL PVLTEFLKLD VQLVLVGTGD PLLAAQLRDV AAQFGEKFVF
VEAYNNQLAH LVEAASDFFL MPSEFEPCGL NQIYSMAYGS LPIVRGVGGL KDSVCDYDVN
PETATGFVFY EPTAQALLIT MQRALLLYAQ NLTELRRVQL YAMERDFCWN KAAEQYVELY
RSALK
