GLGA_YERPG
ID GLGA_YERPG Reviewed; 476 AA.
AC A9R5M0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Glycogen synthase {ECO:0000255|HAMAP-Rule:MF_00484};
DE EC=2.4.1.21 {ECO:0000255|HAMAP-Rule:MF_00484};
DE AltName: Full=Starch [bacterial glycogen] synthase {ECO:0000255|HAMAP-Rule:MF_00484};
GN Name=glgA {ECO:0000255|HAMAP-Rule:MF_00484};
GN OrderedLocusNames=YpAngola_A4121;
OS Yersinia pestis bv. Antiqua (strain Angola).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=349746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Angola;
RX PubMed=20061468; DOI=10.1128/jb.01518-09;
RA Eppinger M., Worsham P.L., Nikolich M.P., Riley D.R., Sebastian Y., Mou S.,
RA Achtman M., Lindler L.E., Ravel J.;
RT "Genome sequence of the deep-rooted Yersinia pestis strain Angola reveals
RT new insights into the evolution and pangenome of the plague bacterium.";
RL J. Bacteriol. 192:1685-1699(2010).
CC -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00484};
CC -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00484}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC Bacterial/plant glycogen synthase subfamily. {ECO:0000255|HAMAP-
CC Rule:MF_00484}.
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DR EMBL; CP000901; ABX85784.1; -; Genomic_DNA.
DR RefSeq; WP_002209498.1; NZ_CP009935.1.
DR AlphaFoldDB; A9R5M0; -.
DR SMR; A9R5M0; -.
DR CAZy; GT5; Glycosyltransferase Family 5.
DR GeneID; 66843792; -.
DR KEGG; ypg:YpAngola_A4121; -.
DR PATRIC; fig|349746.12.peg.856; -.
DR OMA; TWCPWYM; -.
DR UniPathway; UPA00164; -.
DR GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00484; Glycogen_synth; 1.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR011835; GS/SS.
DR InterPro; IPR013534; Starch_synth_cat_dom.
DR Pfam; PF08323; Glyco_transf_5; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR TIGRFAMs; TIGR02095; glgA; 1.
PE 3: Inferred from homology;
KW Glycogen biosynthesis; Glycosyltransferase; Transferase.
FT CHAIN 1..476
FT /note="Glycogen synthase"
FT /id="PRO_1000126114"
FT BINDING 15
FT /ligand="ADP-alpha-D-glucose"
FT /ligand_id="ChEBI:CHEBI:57498"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00484"
SQ SEQUENCE 476 AA; 52276 MW; A057EA3FEC5B6800 CRC64;
MRVLHVCSEL FPLLKTGGLA DVIGALPAAQ LAEGADVRII LPAFPDLRRG IPETVLVREI
DTFAGRVALR YGHYRGIGIY LIDAPALYDR AGSPYHDASL YAYSDNYLRF ALLGWMACEL
ACGLDGYWRP EVVHAHDWHA GLTCAYLAAR GRPARSVFTV HNLAYQGLFS ADHLSELHLP
AEFFQIYGLE FYGQISYLKA GLFFADHVTT VSPTYAKEIT QPAFGYGMEG LLQALARQGR
LTGILNGVDS DIWDPQSDTL LPTRYDAENL QAKAINKTHL QTAMGLQLAE NKPIFAVVSR
LTVQKGLDLV LEALPELLAL GGQLVVLGSG DATLQEAFLA AAAEHSGQVG VQIGYHEAFS
HRIIAGSDVI LVPSRFEPCG LTQLYGLKYG TLPLVRHTGG LADTVVDCAL ENLADGSASG
FVFNECEAQA LVKAIRRAFV LWSRPKHWRH VQRHAMRLDF GWQLAAVDYL SLYRRL
