ID   GLGL1_WHEAT             Reviewed;         301 AA.
AC   P12298;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Glucose-1-phosphate adenylyltransferase large subunit;
DE            EC=2.7.7.27;
DE   AltName: Full=ADP-glucose pyrophosphorylase;
DE   AltName: Full=ADP-glucose synthase;
DE   AltName: Full=AGPase S;
DE   AltName: Full=Alpha-D-glucose-1-phosphate adenyl transferase;
DE   Flags: Fragment;
GN   Name=AGA.1;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Mardler; TISSUE=Leaf;
RA   Olive M.R., Ellis R.J., Schuch W.W.;
RT   "Isolation and nucloetide sequences of cDNA clones encoding ADP-glucose
RT   pyrophosphorylase polypeptides from wheat leaf and endosperm.";
RL   Plant Mol. Biol. 12:525-538(1989).
CC   -!- FUNCTION: This protein plays a role in synthesis of starch. It
CC       catalyzes the synthesis of the activated glycosyl donor, ADP-glucose
CC       from Glc-1-P and ATP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose
CC         + diphosphate; Xref=Rhea:RHEA:12120, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57498,
CC         ChEBI:CHEBI:58601; EC=2.7.7.27;
CC   -!- ACTIVITY REGULATION: Insensitive to 3'phosphoglycerate and
CC       orthophosphate.
CC   -!- PATHWAY: Glycan biosynthesis; starch biosynthesis.
CC   -!- SUBUNIT: Heterotetramer.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast. Plastid, amyloplast.
CC       Note=Found in the chloroplast in leaf. Found in the plastid in the
CC       developing endosperm.
CC   -!- SIMILARITY: Belongs to the bacterial/plant glucose-1-phosphate
CC       adenylyltransferase family. {ECO:0000305}.
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DR   EMBL; X14348; CAA32531.1; -; mRNA.
DR   PIR; S05079; S05079.
DR   AlphaFoldDB; P12298; -.
DR   SMR; P12298; -.
DR   STRING; 4565.Traes_5BL_3212A5875.1; -.
DR   PRIDE; P12298; -.
DR   eggNOG; KOG1322; Eukaryota.
DR   UniPathway; UPA00152; -.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; P12298; baseline and differential.
DR   GO; GO:0009501; C:amyloplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008878; F:glucose-1-phosphate adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:InterPro.
DR   GO; GO:0019252; P:starch biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR011831; ADP-Glc_PPase.
DR   InterPro; IPR005836; ADP_Glu_pyroP_CS.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   PANTHER; PTHR43523; PTHR43523; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   PROSITE; PS00810; ADP_GLC_PYROPHOSPH_3; 1.
PE   2: Evidence at transcript level;
KW   Allosteric enzyme; Amyloplast; ATP-binding; Chloroplast;
KW   Nucleotide-binding; Nucleotidyltransferase; Plastid; Reference proteome;
KW   Starch biosynthesis; Transferase.
FT   CHAIN           <1..301
FT                   /note="Glucose-1-phosphate adenylyltransferase large
FT                   subunit"
FT                   /id="PRO_0000195359"
FT   NON_TER         1
SQ   SEQUENCE   301 AA;  33430 MW;  6248A1903BBD8003 CRC64;
     GVLILSGDHL YRMDYMDFVQ SHRQRDAGIS ICCLPIDGSR ASDFGLMKID DTGRVISFSE
     KPRGADLKEM EEAEKKPYIA SMGVYIFKKE ILLNLLRWRF PTANDFGSEI IPAAAREINV
     KAYLFNDYWE DIGTIKSFFE ANLALAEQPS KFSFYDASKP MYTSRRNLPP SMISGSKITD
     SIISHGCFLD KCRVEHSVVG IRSRIGSNVH LKDTVMLGAD FYETDMERGD QLAEGKVPIG
     IGENTSIQNC IIDKNARIGK NVTIANAEGV QEADRASEGF HIRSGITVVL KNSVIADGLV
     I