ID   GLGSY_MYCTO             Reviewed;         414 AA.
AC   P9WMY8; L0TCY4; O53279; Q7D693;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Glycogen synthase;
DE            EC=2.4.1.11;
DE   AltName: Full=Alpha-1,4-glucosyltransferase MT3116;
DE   AltName: Full=UDP-glucose--glycogen glucosyltransferase;
GN   OrderedLocusNames=MT3116;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Glucosyltransferase that uses UDP-glucose as the sugar donor
CC       to elongate alpha-(1->4)-glucans. Is involved in the biosynthesis of
CC       both 6-O-methylglucosyl lipopolysaccharides (MGLP) and glycogen. May
CC       also use ADP-glucose as substrate (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:18549, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.11;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47446.1; -; Genomic_DNA.
DR   PIR; C70859; C70859.
DR   RefSeq; WP_003415928.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMY8; -.
DR   SMR; P9WMY8; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   EnsemblBacteria; AAK47446; AAK47446; MT3116.
DR   KEGG; mtc:MT3116; -.
DR   PATRIC; fig|83331.31.peg.3358; -.
DR   HOGENOM; CLU_009583_2_3_11; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR028098; Glyco_trans_4-like_N.
DR   Pfam; PF13439; Glyco_transf_4; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Glycogen biosynthesis; Glycogen metabolism;
KW   Glycosyltransferase; Transferase.
FT   CHAIN           1..414
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000427219"
SQ   SEQUENCE   414 AA;  44805 MW;  64ADC7A4EA17A0DE CRC64;
     MRILMVSWEY PPVVIGGLGR HVHHLSTALA AAGHDVVVLS RCPSGTDPST HPSSDEVTEG
     VRVIAAAQDP HEFTFGNDMM AWTLAMGHAM IRAGLRLKKL GTDRSWRPDV VHAHDWLVAH
     PAIALAQFYD VPMVSTIHAT EAGRHSGWVS GALSRQVHAV ESWLVRESDS LITCSASMND
     EITELFGPGL AEITVIRNGI DAARWPFAAR RPRTGPAELL YVGRLEYEKG VHDAIAALPR
     LRRTHPGTTL TIAGEGTQQD WLIDQARKHR VLRATRFVGH LDHTELLALL HRADAAVLPS
     HYEPFGLVAL EAAAAGTPLV TSNIGGLGEA VINGQTGVSC APRDVAGLAA AVRSVLDDPA
     AAQRRARAAR QRLTSDFDWQ TVATATAQVY LAAKRGERQP QPRLPIVEHA LPDR