ID   3S11_MICTC              Reviewed;          57 AA.
AC   C0HLK3;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   12-AUG-2020, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Three-finger toxin Tschuditoxin-I {ECO:0000303|PubMed:31211957};
DE   Flags: Fragment;
OS   Micrurus tschudii (Desert coral snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=2527855 {ECO:0000303|PubMed:31211957};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000303|PubMed:31211957};
RX   PubMed=31211957; DOI=10.1016/j.toxicon.2019.06.023;
RA   Lomonte B., Camacho E., Fernandez J., Salas M., Zavaleta A.;
RT   "Three-finger toxins from the venom of Micrurus tschudii tschudii (desert
RT   coral snake): Isolation and characterization of tschuditoxin-I.";
RL   Toxicon 167:144-151(2019).
CC   -!- FUNCTION: Produces peripheral paralysis by blocking neuromuscular
CC       transmission at the postsynaptic site (By similarity). Binds to and
CC       inhibits the endogenous nicotinic acetylcholine receptors (nAChR) (By
CC       similarity). This neurotoxin is lethal to mice by intraperitoneal or
CC       intravenous injection (PubMed:31211957). {ECO:0000250|UniProtKB:P86095,
CC       ECO:0000269|PubMed:31211957}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31211957}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:31211957}.
CC   -!- MASS SPECTROMETRY: Mass=6538.8; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:31211957};
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; C0HLK3; -.
DR   SMR; C0HLK3; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
DR   GO; GO:0035821; P:modulation of process of another organism; IDA:UniProtKB.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..>57
FT                   /note="Three-finger toxin Tschuditoxin-I"
FT                   /id="PRO_0000450618"
FT   DISULFID        3..22
FT                   /evidence="ECO:0000250|UniProtKB:P01426"
FT   DISULFID        17..39
FT                   /evidence="ECO:0000250|UniProtKB:P01426"
FT   DISULFID        41..52
FT                   /evidence="ECO:0000250|UniProtKB:P01426"
FT   UNSURE          45
FT                   /note="K or Q"
FT                   /evidence="ECO:0000269|PubMed:31211957"
FT   UNSURE          50
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:31211957"
FT   NON_TER         57
FT                   /evidence="ECO:0000303|PubMed:31211957"
SQ   SEQUENCE   57 AA;  6286 MW;  869FFEC4760ED476 CRC64;
     MICYNQQSSE PPTTKTCSEG QCYKKTWSDH RGTIIERGCA CPNVKPGVKI SCCSSDK