ID   GLHA2_CYPCA             Reviewed;         118 AA.
AC   P18857;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Glycoprotein hormones alpha chain 2;
DE   AltName: Full=GTH-alpha;
DE   AltName: Full=Gonadotropin alpha chain 2;
DE   Flags: Precursor;
GN   Name=cgab; Synonyms=cgb;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3246480; DOI=10.1111/j.1399-3011.1988.tb01387.x;
RA   Chang Y.S., Huang C.-J., Huang F.-L., Lo T.-B.;
RT   "Primary structures of carp gonadotropin subunits deduced from cDNA
RT   nucleotide sequences.";
RL   Int. J. Pept. Protein Res. 32:556-564(1988).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; M37380; AAA49210.1; -; mRNA.
DR   PIR; A40554; A40554.
DR   AlphaFoldDB; P18857; -.
DR   SMR; P18857; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR000476; Glyco_hormone.
DR   PANTHER; PTHR11509; PTHR11509; 1.
DR   Pfam; PF00236; Hormone_6; 1.
DR   PRINTS; PR00274; GLYCOHORMONE.
DR   SMART; SM00067; GHA; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR   PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR   PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..118
FT                   /note="Glycoprotein hormones alpha chain 2"
FT                   /id="PRO_0000011666"
FT   CARBOHYD        79
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        34..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..87
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        86..113
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   118 AA;  13548 MW;  DFB590F899EFCF1E CRC64;
     MFWTRYAGAS VLLFLMLIHL GQLYPRNYMN NFGCEECKLK ENNIFSKPGA PVYQCMGCCF
     SRAYPTPLRS KKTMLVPKNI TSEATCCVAK EFKQVLVNDI KLVNHTDCHC STCYYHKS