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GLHA2_ONCKE
ID   GLHA2_ONCKE             Reviewed;         114 AA.
AC   P69063; P13153;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Glycoprotein hormones alpha chain 2;
DE   AltName: Full=GTH-alpha;
DE   AltName: Full=Gonadotropin 2 alpha chain;
DE   Flags: Precursor;
GN   Name=cgab;
OS   Oncorhynchus keta (Chum salmon) (Salmo keta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8018;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2466605; DOI=10.1016/0305-0491(88)90020-x;
RA   Kitahara N., Nishizawa T., Gatanaga T., Okazaki H., Andoh T., Soma G.;
RT   "Primary structure of two mRNAs encoding putative salmon alpha-subunits of
RT   pituitary glycoprotein hormone.";
RL   Comp. Biochem. Physiol. 91B:551-556(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2813416; DOI=10.1073/pnas.86.22.8645;
RA   Sekine S., Saito A., Itoh H., Kawauchi H., Itoh S.;
RT   "Molecular cloning and sequence analysis of chum salmon gonadotropin
RT   cDNAs.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:8645-8649(1989).
CC   -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC       {ECO:0000305}.
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DR   EMBL; M27653; AAA49405.1; -; mRNA.
DR   EMBL; M27152; AAA49407.1; -; mRNA.
DR   PIR; JL0069; B60627.
DR   AlphaFoldDB; P69063; -.
DR   SMR; P69063; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR000476; Glyco_hormone.
DR   PANTHER; PTHR11509; PTHR11509; 1.
DR   Pfam; PF00236; Hormone_6; 1.
DR   PRINTS; PR00274; GLYCOHORMONE.
DR   SMART; SM00067; GHA; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR   PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR   PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT   SIGNAL          1..22
FT   CHAIN           23..114
FT                   /note="Glycoprotein hormones alpha chain 2"
FT                   /id="PRO_0000011670"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        33..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        36..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        50..104
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..109
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   114 AA;  12538 MW;  39FBF7AFDF1E33D7 CRC64;
     MCLLKSTGLS LILSALLVIA DSYPNSDKTN MGCEECTLKP NTIFPNIMQC TGCCFSRAYP
     TPLRSKQTML VPKNITSEAT CCVAKEGERV TTKDGFPVTN HTECHCSTCY YHKS
 
 
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