GLHA2_ONCKE
ID GLHA2_ONCKE Reviewed; 114 AA.
AC P69063; P13153;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 48.
DE RecName: Full=Glycoprotein hormones alpha chain 2;
DE AltName: Full=GTH-alpha;
DE AltName: Full=Gonadotropin 2 alpha chain;
DE Flags: Precursor;
GN Name=cgab;
OS Oncorhynchus keta (Chum salmon) (Salmo keta).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8018;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2466605; DOI=10.1016/0305-0491(88)90020-x;
RA Kitahara N., Nishizawa T., Gatanaga T., Okazaki H., Andoh T., Soma G.;
RT "Primary structure of two mRNAs encoding putative salmon alpha-subunits of
RT pituitary glycoprotein hormone.";
RL Comp. Biochem. Physiol. 91B:551-556(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2813416; DOI=10.1073/pnas.86.22.8645;
RA Sekine S., Saito A., Itoh H., Kawauchi H., Itoh S.;
RT "Molecular cloning and sequence analysis of chum salmon gonadotropin
RT cDNAs.";
RL Proc. Natl. Acad. Sci. U.S.A. 86:8645-8649(1989).
CC -!- FUNCTION: Involved in gametogenesis and steroidogenesis.
CC -!- SUBUNIT: Heterodimer of an alpha and a beta chain.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC {ECO:0000305}.
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DR EMBL; M27653; AAA49405.1; -; mRNA.
DR EMBL; M27152; AAA49407.1; -; mRNA.
DR PIR; JL0069; B60627.
DR AlphaFoldDB; P69063; -.
DR SMR; P69063; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000476; Glyco_hormone.
DR PANTHER; PTHR11509; PTHR11509; 1.
DR Pfam; PF00236; Hormone_6; 1.
DR PRINTS; PR00274; GLYCOHORMONE.
DR SMART; SM00067; GHA; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT SIGNAL 1..22
FT CHAIN 23..114
FT /note="Glycoprotein hormones alpha chain 2"
FT /id="PRO_0000011670"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 33..53
FT /evidence="ECO:0000250"
FT DISULFID 36..82
FT /evidence="ECO:0000250"
FT DISULFID 50..104
FT /evidence="ECO:0000250"
FT DISULFID 54..106
FT /evidence="ECO:0000250"
FT DISULFID 81..109
FT /evidence="ECO:0000250"
SQ SEQUENCE 114 AA; 12538 MW; 39FBF7AFDF1E33D7 CRC64;
MCLLKSTGLS LILSALLVIA DSYPNSDKTN MGCEECTLKP NTIFPNIMQC TGCCFSRAYP
TPLRSKQTML VPKNITSEAT CCVAKEGERV TTKDGFPVTN HTECHCSTCY YHKS