位置:首页 > 蛋白库 > GLHA_MELGA
GLHA_MELGA
ID   GLHA_MELGA              Reviewed;         120 AA.
AC   P68241; P37035;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Glycoprotein hormones alpha chain;
DE   AltName: Full=Anterior pituitary glycoprotein hormones common subunit alpha;
DE   AltName: Full=Follicle-stimulating hormone alpha chain;
DE            Short=FSH-alpha;
DE   AltName: Full=Follitropin alpha chain;
DE   AltName: Full=Luteinizing hormone alpha chain;
DE            Short=LSH-alpha;
DE   AltName: Full=Lutropin alpha chain;
DE   AltName: Full=Thyroid-stimulating hormone alpha chain;
DE            Short=TSH-alpha;
DE   AltName: Full=Thyrotropin alpha chain;
DE   Flags: Precursor;
GN   Name=CGA;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1723796; DOI=10.3382/ps.0702516;
RA   Foster D.N., Foster L.K.;
RT   "Cloning and sequence analysis of the common alpha-subunit complementary
RT   deoxyribonucleic acid of turkey pituitary glycoprotein hormones.";
RL   Poult. Sci. 70:2516-2523(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 34-61.
RX   PubMed=1701134; DOI=10.1210/endo-127-6-2985;
RA   Bergert E.R., Madden B., McCormick D.J., Papkoff H., Ryan R.J.;
RT   "The antigenic structure of the human glycoprotein hormone alpha-subunit:
RT   II. Cross-species comparisons.";
RL   Endocrinology 127:2985-2989(1990).
CC   -!- FUNCTION: Shared alpha chain of heterodimeric glycoprotein hormones.
CC       These hormones bind specific receptors on target cells that in turn
CC       activate downstream signaling pathways. {ECO:0000250|UniProtKB:P01215}.
CC   -!- SUBUNIT: Heterodimer. Glycoprotein hormones are heterodimers composed
CC       of a common alpha chain described here and a unique beta chain which
CC       confers their biological specificity to the different hormones.
CC       {ECO:0000250|UniProtKB:P01215}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01215}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M33698; AAA49629.1; -; mRNA.
DR   PIR; A45585; A45585.
DR   RefSeq; NP_001290106.1; NM_001303177.1.
DR   RefSeq; XP_019468017.1; XM_019612472.1.
DR   RefSeq; XP_019468018.1; XM_019612473.1.
DR   AlphaFoldDB; P68241; -.
DR   SMR; P68241; -.
DR   Ensembl; ENSMGAT00000015400; ENSMGAP00000014464; ENSMGAG00000013689.
DR   GeneID; 100303682; -.
DR   KEGG; mgp:100303682; -.
DR   CTD; 1081; -.
DR   GeneTree; ENSGT00390000012242; -.
DR   HOGENOM; CLU_148106_0_0_1; -.
DR   InParanoid; P68241; -.
DR   OMA; ATVMGNT; -.
DR   OrthoDB; 1430707at2759; -.
DR   TreeFam; TF332733; -.
DR   Proteomes; UP000001645; Chromosome 2.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0016914; C:follicle-stimulating hormone complex; ISS:UniProtKB.
DR   GO; GO:0016913; F:follicle-stimulating hormone activity; ISS:UniProtKB.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
DR   GO; GO:0046884; P:follicle-stimulating hormone secretion; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0008406; P:gonad development; IEA:Ensembl.
DR   GO; GO:0032275; P:luteinizing hormone secretion; IEA:Ensembl.
DR   GO; GO:0046621; P:negative regulation of organ growth; IEA:Ensembl.
DR   GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR   GO; GO:0010893; P:positive regulation of steroid biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0010469; P:regulation of signaling receptor activity; ISS:UniProtKB.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   GO; GO:0006590; P:thyroid hormone generation; IEA:Ensembl.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR000476; Glyco_hormone.
DR   PANTHER; PTHR11509; PTHR11509; 1.
DR   Pfam; PF00236; Hormone_6; 1.
DR   PRINTS; PR00274; GLYCOHORMONE.
DR   SMART; SM00067; GHA; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1.
DR   PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1.
DR   PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..120
FT                   /note="Glycoprotein hormones alpha chain"
FT                   /id="PRO_0000011658"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
FT   DISULFID        35..59
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
FT   DISULFID        38..88
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
FT   DISULFID        56..110
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
FT   DISULFID        60..112
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
FT   DISULFID        87..115
FT                   /evidence="ECO:0000250|UniProtKB:P01215"
SQ   SEQUENCE   120 AA;  13591 MW;  F4662BA0CB6005EB CRC64;
     MDCYRKYAAV TLTILSVFLH LLHTFPDGEF LMQGCPECKL GENRFFSKPG APIYQCTGCC
     FSRAYPTPMR SKKTMLVPKN ITSEATCCVA KAFTKITLKD NVKIENHTDC HCSTCYYHKS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024