ID   GLHR_ANTEL              Reviewed;         925 AA.
AC   P35409;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable glycoprotein hormone G-protein coupled receptor;
DE   Flags: Precursor;
OS   Anthopleura elegantissima (Green aggregating anemone) (Actinia
OS   elegantissima).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Actiniidae; Anthopleura.
OX   NCBI_TaxID=6110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RX   PubMed=8280121; DOI=10.1006/bbrc.1993.2586;
RA   Nothacker H.-P., Grimmelikhuijzen C.J.P.;
RT   "Molecular cloning of a novel, putative G protein-coupled receptor from sea
RT   anemones structurally related to members of the FSH, TSH, LH/CG receptor
RT   family from mammals.";
RL   Biochem. Biophys. Res. Commun. 197:1062-1069(1993).
CC   -!- FUNCTION: Probable receptor for a glycoprotein hormone.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P35409-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P35409-2; Sequence=VSP_001983;
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       FSH/LSH/TSH subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; Z28332; CAA82186.1; -; mRNA.
DR   PIR; JC2033; JC2033.
DR   AlphaFoldDB; P35409; -.
DR   SMR; P35409; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002131; Gphrmn_rcpt_fam.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   PRINTS; PR00373; GLYCHORMONER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM00369; LRR_TYP; 3.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; G-protein coupled receptor;
KW   Glycoprotein; Leucine-rich repeat; Membrane; Receptor; Repeat; Signal;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..925
FT                   /note="Probable glycoprotein hormone G-protein coupled
FT                   receptor"
FT                   /id="PRO_0000012790"
FT   TOPO_DOM        28..529
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        530..551
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        552..561
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        562..584
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        585..606
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        607..628
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        629..651
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        652..673
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        674..691
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        692..712
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        713..739
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        740..763
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        764..774
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        775..795
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        796..925
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          85..106
FT                   /note="LRR 1"
FT   REPEAT          110..131
FT                   /note="LRR 2"
FT   REPEAT          134..155
FT                   /note="LRR 3"
FT   REPEAT          156..180
FT                   /note="LRR 4"
FT   REPEAT          181..202
FT                   /note="LRR 5"
FT   REPEAT          203..224
FT                   /note="LRR 6"
FT   REPEAT          230..250
FT                   /note="LRR 7"
FT   REPEAT          251..273
FT                   /note="LRR 8"
FT   REPEAT          333..349
FT                   /note="1; truncated"
FT   REPEAT          350..384
FT                   /note="2"
FT   REPEAT          385..419
FT                   /note="3"
FT   REPEAT          420..453
FT                   /note="4"
FT   REPEAT          454..461
FT                   /note="5; truncated"
FT   REGION          299..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..461
FT                   /note="5 X approximate tandem repeats"
FT   REGION          904..925
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..341
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..449
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        435
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        495
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         235..925
FT                   /note="Missing (in isoform Short)"
FT                   /evidence="ECO:0000303|PubMed:8280121"
FT                   /id="VSP_001983"
SQ   SEQUENCE   925 AA;  100060 MW;  D03A256368452FBD CRC64;
     MEDRGICPRV LQVLFLVVLI LISPVYAAKN DACTKCSCNP KGMVSCFELQ EFPPLATFPR
     NTTTLHVSFS GEISIPSDIL QHLEKLKYLT LNNNKIKNIA KFRVKNGYSS LITLSYTHNI
     IETIENGAFD DLQQLTQLDL SNNRLKEFPI FNKTSSVTKL YLRGNPGITK LPRQSLGNLP
     SLENLFMERT GIQEIPAGIF RQNTRLINLY FNKTKALERI NEDAFDEDSS LKTLVLDETS
     VTSLPSRGLK NLHFLSLKDV PNFWQLPELD SIREVYLSPY NGFLCCEFES GEKYGKDCTM
     QKPSTEENNG QTTASSPTKE PATSGLGGGT HLSTQPHTTS GFGGGGFPGG GGGFPGGGGF
     PAGGSKTSTQ PHTTSGFGGG GFPGGGGGFP GGGGFPAGGS KTSTQPHTTS GFGGGGFPGG
     GGGFPGGGGF PGGSNTSTQP HTTSNSGGGG FPGGGGFPGG GTPFTNQFTI PHIPNVHQST
     ADPPTLIPHS NHTPNGTQFH QCSKIPVQCV PKSDAFHPCE DIMGYVWLTV VSFMVGAVAL
     VANLVVALVL LTSQRRLNVT RFLMCNLAFA DFILGLYIFI LTSVSAVTRG DYHNYVQQWQ
     NGAGCKILGF LAVFSSELSL FTLVMMTIER FYAIVHAMHM NARLSFRKTV RFMIGGWIFA
     LVMAVVPLTG VSGYSKVAIC LPFDVSDATS TAYVAFLLLV NGASFISVMY LYSRMLYVVV
     SGGDMEGAPK RNDSKVAKRM AILVFTDMLC WAPIAFFGLL AAFGQTLLTV TQSKILLVFF
     FPINSICNPF LYAFFTKAFK RELFTALSRI GFCKFRALKY NGTLSSFLYS RSRRHHSTVN
     AEHSTPKSKH ASTMSLRQSH QDLYRKESKT AESLNGICNA GFNAHEETRT SPGSVRYVRS
     LRGVTKSSSP PHLKLQKQKI LQSPS