ID   GLIAD_RAT               Reviewed;         109 AA.
AC   D3Z9M3;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Gliadoralin-A {ECO:0000303|PubMed:23637100};
DE   Flags: Precursor;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS
RP   SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-17, AND PROTEOLYTIC
RP   PROCESSING.
RX   PubMed=23637100; DOI=10.1002/jssc.201300312;
RA   Cabras T., Iavarone F., Pirolli D., De Rosa M.C., Vitali A., Faa G.,
RA   Cordaro M., Messana I., Ekstroem J., Castagnola M.;
RT   "Top-down HPLC-ESI-MS characterization of rat gliadoralin A, a new member
RT   of the family of rat submandibular gland glutamine-rich proteins and
RT   potential substrate of transglutaminase.";
RL   J. Sep. Sci. 36:2848-2861(2013).
CC   -!- FUNCTION: May play a role in the formation of the protective mucosal
CC       protein pellicle involved in the reinforcement and protection of oral
CC       mucosal epithelial surface. {ECO:0000305|PubMed:23637100}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23637100}.
CC   -!- TISSUE SPECIFICITY: Found in saliva (at protein level). Secreted from
CC       the submandibular gland. {ECO:0000269|PubMed:23637100}.
CC   -!- INDUCTION: By isoprenaline. Prolongend stimulation does not change the
CC       percentages of secreted forms (with gliadoralin A 1-90 as predominant
CC       form). {ECO:0000269|PubMed:23637100}.
CC   -!- PTM: Predominantly proteolytically processed at its C-terminus before
CC       secretion to produce the major form gliadoralin A 1-90. Further
CC       proteloytically processed after secretion to produce minor forms.
CC       Potential substrate of transglutaminase. {ECO:0000305|PubMed:23637100}.
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DR   EMBL; AABR07062288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473964; EDM01680.1; -; Genomic_DNA.
DR   RefSeq; NP_001102119.1; NM_001108649.1.
DR   RefSeq; XP_006237530.1; XM_006237468.3.
DR   AlphaFoldDB; D3Z9M3; -.
DR   STRING; 10116.ENSRNOP00000058891; -.
DR   PaxDb; D3Z9M3; -.
DR   Ensembl; ENSRNOT00000067909; ENSRNOP00000058891; ENSRNOG00000042018.
DR   GeneID; 362451; -.
DR   KEGG; rno:362451; -.
DR   UCSC; RGD:1306750; rat.
DR   CTD; 362451; -.
DR   RGD; 1306750; RGD1306750.
DR   HOGENOM; CLU_174146_0_0_1; -.
DR   InParanoid; D3Z9M3; -.
DR   OMA; SSHNNRE; -.
DR   PRO; PR:D3Z9M3; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Proteomes; UP000234681; Chromosome 4.
DR   Bgee; ENSRNOG00000042018; Expressed in heart and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|PubMed:23637100"
FT   CHAIN           17..106
FT                   /note="Gliadoralin-A"
FT                   /evidence="ECO:0000269|PubMed:23637100"
FT                   /id="PRO_5008161006"
FT   PROPEP          107..109
FT                   /evidence="ECO:0000269|PubMed:23637100"
FT                   /id="PRO_0000439193"
FT   REGION          17..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         17
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:23637100"
SQ   SEQUENCE   109 AA;  12547 MW;  D627EFDBF7FF2AF8 CRC64;
     MLVILLMVVV LALSSAQDPN RDFVVSSQDV RERQPSSQQG TVGGQSQESQ LRDQQQQQSL
     QQSQEQQPQP QLQQTKQPQR PVKGQPLPQQ QQQQNQRPRP RYQQPRRAV