GLIP1_HUMAN
ID GLIP1_HUMAN Reviewed; 266 AA.
AC P48060; A7YET6; F8VUC2; Q15409; Q969K2;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 3.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Glioma pathogenesis-related protein 1;
DE Short=GliPR 1;
DE AltName: Full=Protein RTVP-1;
DE Flags: Precursor;
GN Name=GLIPR1; Synonyms=GLIPR, RTVP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=7607567; DOI=10.1016/0378-1119(95)00061-a;
RA Murphy E.V., Zhang Y., Zhu W., Biggs J.;
RT "The human glioma pathogenesis-related protein is structurally related to
RT plant pathogenesis-related proteins and its gene is expressed specifically
RT in brain tumors.";
RL Gene 159:131-135(1995).
RN [2]
RP SEQUENCE REVISION.
RA Murphy E.V.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Glial tumor;
RX PubMed=8973356; DOI=10.1016/s0378-1119(96)00431-3;
RA Rich T., Chen P., Furman F., Huynh N., Israel M.A.;
RT "RTVP-1, a novel human gene with sequence similarity to genes of diverse
RT species, is expressed in tumor cell lines of glial but not neuronal
RT origin.";
RL Gene 180:125-130(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Glial tumor;
RX PubMed=17825796; DOI=10.1016/j.bbrc.2007.08.138;
RA Xiang C., Sarid R., Cazacu S., Finniss S., Lee H.K., Ziv-Av A.,
RA Mikkelsen T., Brodie C.;
RT "Cloning and characterization of human RTVP-1b, a novel splice variant of
RT RTVP-1 in glioma cells.";
RL Biochem. Biophys. Res. Commun. 362:612-618(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wu J., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP STRUCTURE BY NMR.
RX PubMed=9482873; DOI=10.1073/pnas.95.5.2262;
RA Szyperski T., Fernandez C., Mumenthaler C., Wuethrich K.;
RT "Structure comparison of human glioma pathogenesis-related protein GliPR
RT and the plant pathogenesis-related protein P14a indicates a functional link
RT between the human immune system and a plant defense system.";
RL Proc. Natl. Acad. Sci. U.S.A. 95:2262-2266(1998).
CC -!- INTERACTION:
CC P48060; P42858: HTT; NbExp=3; IntAct=EBI-2833130, EBI-466029;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P48060-1; Sequence=Displayed;
CC Name=2; Synonyms=RTVP-1b;
CC IsoId=P48060-2; Sequence=VSP_043902;
CC -!- TISSUE SPECIFICITY: According to PubMed:8973356, it is ubiquitously
CC expressed with high levels in lung and kidney and low levels in heart
CC and liver. Highly expressed in cell lines derived from nervous system
CC tumors arising from glia, low or absent in non-glial-derived nervous
CC system tumor cell lines. Also found in fetal kidney. According to
CC PubMed:7607567 it is expressed only in brain tumor glioblastoma
CC multiforme/astrocytoma and not in other nervous system tumors or normal
CC fetal or adult tissues.
CC -!- MISCELLANEOUS: [Isoform 2]: Highly expressed in glioblastomas.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA82731.3; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U16307; AAA82731.3; ALT_FRAME; mRNA.
DR EMBL; X91911; CAA63005.1; -; mRNA.
DR EMBL; AF400440; AAK92489.1; -; mRNA.
DR EMBL; EF667354; ABV21587.1; -; mRNA.
DR EMBL; BC012510; AAH12510.1; -; mRNA.
DR CCDS; CCDS9011.1; -. [P48060-1]
DR PIR; JC4131; JC4131.
DR PIR; JC5308; JC5308.
DR RefSeq; NP_006842.2; NM_006851.2. [P48060-1]
DR PDB; 3Q2R; X-ray; 2.20 A; A=22-220.
DR PDB; 3Q2U; X-ray; 1.85 A; A=22-220.
DR PDBsum; 3Q2R; -.
DR PDBsum; 3Q2U; -.
DR AlphaFoldDB; P48060; -.
DR SMR; P48060; -.
DR BioGRID; 116200; 15.
DR IntAct; P48060; 10.
DR MINT; P48060; -.
DR STRING; 9606.ENSP00000266659; -.
DR DrugBank; DB05337; SOT-107.
DR TCDB; 8.B.9.1.7; the triflin toxin (triflin or crisp) family.
DR iPTMnet; P48060; -.
DR PhosphoSitePlus; P48060; -.
DR BioMuta; GLIPR1; -.
DR DMDM; 27735198; -.
DR EPD; P48060; -.
DR jPOST; P48060; -.
DR MassIVE; P48060; -.
DR MaxQB; P48060; -.
DR PaxDb; P48060; -.
DR PeptideAtlas; P48060; -.
DR PRIDE; P48060; -.
DR ProteomicsDB; 55851; -. [P48060-1]
DR ProteomicsDB; 55852; -. [P48060-2]
DR Antibodypedia; 2474; 166 antibodies from 28 providers.
DR DNASU; 11010; -.
DR Ensembl; ENST00000266659.8; ENSP00000266659.3; ENSG00000139278.10. [P48060-1]
DR GeneID; 11010; -.
DR KEGG; hsa:11010; -.
DR MANE-Select; ENST00000266659.8; ENSP00000266659.3; NM_006851.3; NP_006842.2.
DR UCSC; uc001sxs.4; human. [P48060-1]
DR CTD; 11010; -.
DR DisGeNET; 11010; -.
DR GeneCards; GLIPR1; -.
DR HGNC; HGNC:17001; GLIPR1.
DR HPA; ENSG00000139278; Low tissue specificity.
DR MIM; 602692; gene.
DR neXtProt; NX_P48060; -.
DR OpenTargets; ENSG00000139278; -.
DR PharmGKB; PA134988403; -.
DR VEuPathDB; HostDB:ENSG00000139278; -.
DR eggNOG; KOG3017; Eukaryota.
DR GeneTree; ENSGT00940000160727; -.
DR HOGENOM; CLU_035730_2_0_1; -.
DR InParanoid; P48060; -.
DR OMA; NEIQYYD; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; P48060; -.
DR TreeFam; TF316148; -.
DR PathwayCommons; P48060; -.
DR Reactome; R-HSA-1989781; PPARA activates gene expression.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; P48060; -.
DR BioGRID-ORCS; 11010; 14 hits in 1068 CRISPR screens.
DR ChiTaRS; GLIPR1; human.
DR EvolutionaryTrace; P48060; -.
DR GeneWiki; GLIPR1; -.
DR GenomeRNAi; 11010; -.
DR Pharos; P48060; Tbio.
DR PRO; PR:P48060; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; P48060; protein.
DR Bgee; ENSG00000139278; Expressed in monocyte and 190 other tissues.
DR ExpressionAtlas; P48060; baseline and differential.
DR Genevisible; P48060; HS.
DR GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR CDD; cd05385; CAP_GLIPR1-like; 1.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR034121; SCP_GLIPR-1-like.
DR InterPro; IPR002413; V5_allergen-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00838; V5ALLERGEN.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..266
FT /note="Glioma pathogenesis-related protein 1"
FT /id="PRO_0000006270"
FT TRANSMEM 233..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 38..175
FT /note="SCP"
FT VAR_SEQ 142..266
FT /note="VWADSYKVGCAVQFCPKVSGFDALSNGAHFICNYGPGGNYPTWPYKRGATCS
FT ACPNNDKCLDNLCVNRQRDQVKRYYSVVYPGWPIYPRNRYTSLFLIVNSVILILSVIIT
FT ILVQHKYPNLVLLD -> SQERGRDPNPKRGFLNLARENPGLFGQIVTKLAAQFNFALK
FT FLALTLFPMEHILYATTDQEGITQLGHIREEPPAVPAPIMTSVWTISVLTDSETK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:17825796"
FT /id="VSP_043902"
FT VARIANT 163
FT /note="D -> E (in dbSNP:rs28932170)"
FT /id="VAR_061128"
FT VARIANT 211
FT /note="R -> Q (in dbSNP:rs3736392)"
FT /id="VAR_048833"
FT CONFLICT 257
FT /note="H -> L (in Ref. 3; CAA63005)"
FT /evidence="ECO:0000305"
FT HELIX 31..46
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:3Q2U"
FT HELIX 62..72
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 97..104
FT /evidence="ECO:0007829|PDB:3Q2U"
FT TURN 105..107
FT /evidence="ECO:0007829|PDB:3Q2U"
FT HELIX 110..118
FT /evidence="ECO:0007829|PDB:3Q2U"
FT HELIX 119..123
FT /evidence="ECO:0007829|PDB:3Q2U"
FT TURN 126..129
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 130..133
FT /evidence="ECO:0007829|PDB:3Q2U"
FT HELIX 136..141
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 148..157
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 167..177
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 188..190
FT /evidence="ECO:0007829|PDB:3Q2U"
FT TURN 191..194
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 200..202
FT /evidence="ECO:0007829|PDB:3Q2U"
FT STRAND 205..207
FT /evidence="ECO:0007829|PDB:3Q2U"
FT HELIX 209..212
FT /evidence="ECO:0007829|PDB:3Q2U"
SQ SEQUENCE 266 AA; 30366 MW; C0466C085EFB2B7A CRC64;
MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP TASDMLYMTW
DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI WTGSVPIFSV SSAITNWYDE
IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG CAVQFCPKVS GFDALSNGAH FICNYGPGGN
YPTWPYKRGA TCSACPNNDK CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV
NSVILILSVI ITILVQHKYP NLVLLD
