GLIP1_MOUSE
ID GLIP1_MOUSE Reviewed; 255 AA.
AC Q9CWG1;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Glioma pathogenesis-related protein 1;
DE Short=GliPR 1;
DE Flags: Precursor;
GN Name=Glipr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR EMBL; AK010768; BAB27168.1; -; mRNA.
DR EMBL; BC025083; AAH25083.1; -; mRNA.
DR CCDS; CCDS24169.1; -.
DR RefSeq; NP_082884.1; NM_028608.3.
DR AlphaFoldDB; Q9CWG1; -.
DR SMR; Q9CWG1; -.
DR BioGRID; 216192; 1.
DR STRING; 10090.ENSMUSP00000123990; -.
DR PhosphoSitePlus; Q9CWG1; -.
DR EPD; Q9CWG1; -.
DR MaxQB; Q9CWG1; -.
DR PaxDb; Q9CWG1; -.
DR PRIDE; Q9CWG1; -.
DR ProteomicsDB; 266808; -.
DR Antibodypedia; 2474; 166 antibodies from 28 providers.
DR DNASU; 73690; -.
DR Ensembl; ENSMUST00000074805; ENSMUSP00000074359; ENSMUSG00000056888.
DR Ensembl; ENSMUST00000162508; ENSMUSP00000123990; ENSMUSG00000056888.
DR GeneID; 73690; -.
DR KEGG; mmu:73690; -.
DR UCSC; uc007haj.2; mouse.
DR CTD; 11010; -.
DR MGI; MGI:1920940; Glipr1.
DR VEuPathDB; HostDB:ENSMUSG00000056888; -.
DR eggNOG; KOG3017; Eukaryota.
DR GeneTree; ENSGT00940000160727; -.
DR HOGENOM; CLU_035730_2_0_1; -.
DR InParanoid; Q9CWG1; -.
DR OMA; NEIQYYD; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q9CWG1; -.
DR TreeFam; TF316148; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 73690; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q9CWG1; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CWG1; protein.
DR Bgee; ENSMUSG00000056888; Expressed in granulocyte and 125 other tissues.
DR ExpressionAtlas; Q9CWG1; baseline and differential.
DR Genevisible; Q9CWG1; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR002413; V5_allergen-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00838; V5ALLERGEN.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..255
FT /note="Glioma pathogenesis-related protein 1"
FT /id="PRO_0000006271"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 39..164
FT /note="SCP"
SQ SEQUENCE 255 AA; 29129 MW; A836ECCB3BACD20A CRC64;
MQVILAVIVW MASSVSSSSF TASTLPDITN EDFIKECVQV HNQLRSKVSP PARNMLYMSW
DPKLAQIAKA WTKSCEFKHN PQLHSRIHPN FTALGENIWL GSLSIFSVSS AISAWYEEIK
HYDFSTRKCR HVCGHYTQVV WADSYKLGCA VQLCPNGANF ICDYGPAGNY PTWPYKQGAT
CSDCPKDDKC LNSLCINPRR DQVSRYYSVD YPDWPIYLRN RYTSLFLIAK SVLLLLSVII
TIWVKHKYPN LVLLD
