GLK1_TRIVA
ID GLK1_TRIVA Reviewed; 375 AA.
AC Q9GTW9;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Glucokinase 1;
DE EC=2.7.1.2;
DE AltName: Full=Glucose kinase 1;
DE AltName: Full=Hexokinase-1;
GN Name=GK1;
OS Trichomonas vaginalis.
OC Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC Trichomonas.
OX NCBI_TaxID=5722;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, AND
RP CHARACTERIZATION.
RC STRAIN=ATCC 30001 / NIH-C1;
RX PubMed=11250082; DOI=10.1016/s0378-1119(01)00329-8;
RA Wu G., Henze K., Mueller M.;
RT "Evolutionary relationships of the glucokinase from the amitochondriate
RT protist, Trichomonas vaginalis.";
RL Gene 264:265-271(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC -!- SUBUNIT: Monomer.
CC -!- PTM: The N-terminus is blocked.
CC -!- SIMILARITY: Belongs to the bacterial glucokinase family. {ECO:0000305}.
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DR EMBL; AF248652; AAG17616.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9GTW9; -.
DR SMR; Q9GTW9; -.
DR STRING; 5722.XP_001304619.1; -.
DR VEuPathDB; TrichDB:TVAG_092750; -.
DR eggNOG; ENOG502S3Y5; Eukaryota.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR003836; Glucokinase.
DR Pfam; PF02685; Glucokinase; 1.
DR SUPFAM; SSF53067; SSF53067; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Direct protein sequencing; Glycolysis; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1..375
FT /note="Glucokinase 1"
FT /id="PRO_0000215151"
FT BINDING 25..30
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 375 AA; 41585 MW; 229F76B24637BE21 CRC64;
MFSIDLIQQI KEWKRGSTLP ICLGCDVGGS GLRVRLSDFH DSAKYVDLGH AKAQKTAELL
KVLEDLQQKI LQVEPTTVCL GAAIAVAGPI KNNTVILTNW KGPAEERTLS ITQLPKGLFP
KDRSYFLNDL EAGAYGVIAA YEQSILEENF VQLFTDRAPT GPILAKGRTA VLAMGSGLGA
ALVTRTPLLK NPLVLPTELG HLQIAPNMAT HKYFQDEQEL IQHISDHYYG GKLDPEYEDI
CSGRGLQLAF QFYHKKLTGE VLPLEQIDAG DVAKKAIAGE KDAYNALRAH YIFYLRAAKA
IATSLSCESC VLSLDNQVKN HPFVMKIAKE LEEEFYEFIR PDWMTSVRVY SQKSILNFNI
LGTDYMAHAI ANKPQ