ID   GLK2_TRIVA              Reviewed;         377 AA.
AC   Q9GTW8;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Probable glucokinase 2;
DE            EC=2.7.1.2;
DE   AltName: Full=Glucose kinase 2;
DE   AltName: Full=Hexokinase-2;
GN   Name=GK2;
OS   Trichomonas vaginalis.
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=5722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30001 / NIH-C1;
RX   PubMed=11250082; DOI=10.1016/s0378-1119(01)00329-8;
RA   Wu G., Henze K., Mueller M.;
RT   "Evolutionary relationships of the glucokinase from the amitochondriate
RT   protist, Trichomonas vaginalis.";
RL   Gene 264:265-271(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC   -!- SIMILARITY: Belongs to the bacterial glucokinase family. {ECO:0000305}.
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DR   EMBL; AF248653; AAG17617.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9GTW8; -.
DR   SMR; Q9GTW8; -.
DR   STRING; 5722.XP_001302401.1; -.
DR   VEuPathDB; TrichDB:TVAG_023840; -.
DR   eggNOG; ENOG502S3Y5; Eukaryota.
DR   OMA; YFKVMWK; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR003836; Glucokinase.
DR   Pfam; PF02685; Glucokinase; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Glycolysis; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN           1..377
FT                   /note="Probable glucokinase 2"
FT                   /id="PRO_0000215152"
FT   BINDING         27..32
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   377 AA;  41773 MW;  A4270820B97919DA CRC64;
     MFDIELVKKI NDWKVSEDGA LPICIGCDVG GSGLRVRISS FNDSEKYVDL GHAKAKCTKQ
     LVDVLADLEQ KIKQVNDKFV CLGAAIAVAG PIKAGTVILT NWQGEPAVRT LTLKDLPQKI
     FPKDRSVFLN DLEAGAYGVI AAADKDILEQ NFVQLFQDKA PKGPVLANGR TAVLAMGSGL
     GAALVVRTPL LKNPLVLPTE LGHVQIAPNM KEHKNFKQER ELIQHISNHY YKGELDPEYE
     DICSGRGLPL AYQFYHQKKT GELLPVEQID AGEVAKKAMD GEEDAVDALK AHYIFYLRAA
     KAIATSLSCE SCVLSLDNQV KNHPFVMKIM KELEDEFYEF IRPDWMNGLR VYSQKSILNF
     NILGTDYMAH AIANKPE