ID   GLK_ALKHC               Reviewed;         330 AA.
AC   Q9KCZ4;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Glucokinase;
DE            EC=2.7.1.2;
DE   AltName: Full=Glucose kinase;
GN   Name=glcK; Synonyms=glk; OrderedLocusNames=BH1425;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000004; BAB05144.1; -; Genomic_DNA.
DR   PIR; A83828; A83828.
DR   RefSeq; WP_010897590.1; NC_002570.2.
DR   AlphaFoldDB; Q9KCZ4; -.
DR   SMR; Q9KCZ4; -.
DR   STRING; 272558.10174042; -.
DR   EnsemblBacteria; BAB05144; BAB05144; BAB05144.
DR   KEGG; bha:BH1425; -.
DR   eggNOG; COG1940; Bacteria.
DR   HOGENOM; CLU_036604_0_1_9; -.
DR   OMA; DHLVMIT; -.
DR   OrthoDB; 1130699at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR004654; ROK_glcA.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   TIGRFAMs; TIGR00744; ROK_glcA_fam; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..330
FT                   /note="Glucokinase"
FT                   /id="PRO_0000095675"
SQ   SEQUENCE   330 AA;  34496 MW;  E5448D6CBD87456F CRC64;
     MSDRWYVGVD VGGTTIKMAF LTTAGEIVDK WEIPTNKQDG GALITTNIAD ALDKRLSGHH
     KSKSDLIGIG LGAPGFIEMD TGFIYHAVNI GWRDFPLKDK LEEETKLPVI VDNDANIAAL
     GEMWKGAGDG AKNMLLITLG TGVGGGIVAN GNILHGVNGM AGEIGHITVI PEGGAPCNCG
     KTGCLETVAS ATGIARIATE GVTEHKESQL ALDYDKHGVL TAKDVFSAAD ASDAFALSVV
     DHIAYYLGFA IANLANALNP EKIVIGGGVS KAGDTLLKPI KQHFEAYALP RVADGAEFRI
     ATLGNDAGVI GGGWLVKQQE NSMEKGNETE