ID   3S11_NAJCH              Reviewed;          62 AA.
AC   P34076;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Short neurotoxin 1;
OS   Naja christyi (Christy's water cobra) (Boulengerina christyi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8611;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=1814007; DOI=10.1016/0041-0101(91)90118-b;
RA   Weinstein S.A., Schmidt J.J., Smith L.A.;
RT   "Lethal toxins and cross-neutralization of venoms from the African water
RT   cobras, Boulengerina annulata annulata and Boulengerina christyi.";
RL   Toxicon 29:1315-1327(1991).
CC   -!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR) and
CC       inhibit acetylcholine from binding to the receptor, thereby impairing
CC       neuromuscular transmission. {ECO:0000250|UniProtKB:P60775}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1814007}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 0.083 mg/kg by intraperitoneal injection.
CC       {ECO:0000269|PubMed:1814007}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}.
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DR   PIR; B39327; B39327.
DR   AlphaFoldDB; P34076; -.
DR   SMR; P34076; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..62
FT                   /note="Short neurotoxin 1"
FT                   /evidence="ECO:0000269|PubMed:1814007"
FT                   /id="PRO_0000093570"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        17..41
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        43..54
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
FT   DISULFID        55..60
FT                   /evidence="ECO:0000250|UniProtKB:P0C1Z0"
SQ   SEQUENCE   62 AA;  6894 MW;  F9FCB920BDB21BE2 CRC64;
     MECHNQQSSQ PPTTTHCSGG ETNCYEKRWH DHRGTIIERG CGCPTVKPGV KLNCCTTDKC
     NN