ID   GLK_NOSP7               Reviewed;         341 AA.
AC   B2J224;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Glucokinase {ECO:0000255|HAMAP-Rule:MF_00524};
DE            EC=2.7.1.2 {ECO:0000255|HAMAP-Rule:MF_00524};
DE   AltName: Full=Glucose kinase {ECO:0000255|HAMAP-Rule:MF_00524};
GN   Name=glk {ECO:0000255|HAMAP-Rule:MF_00524}; OrderedLocusNames=Npun_R5075;
OS   Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=63737;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29133 / PCC 73102;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Meeks J.C., Elhai J.,
RA   Campbell E.L., Thiel T., Longmire J., Potts M., Atlas R.;
RT   "Complete sequence of chromosome of Nostoc punctiforme ATCC 29133.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00524};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00524}.
CC   -!- SIMILARITY: Belongs to the bacterial glucokinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00524}.
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DR   EMBL; CP001037; ACC83410.1; -; Genomic_DNA.
DR   RefSeq; WP_012411364.1; NC_010628.1.
DR   AlphaFoldDB; B2J224; -.
DR   SMR; B2J224; -.
DR   STRING; 63737.Npun_R5075; -.
DR   EnsemblBacteria; ACC83410; ACC83410; Npun_R5075.
DR   KEGG; npu:Npun_R5075; -.
DR   eggNOG; COG0837; Bacteria.
DR   HOGENOM; CLU_042582_0_0_3; -.
DR   OMA; NNHWRLS; -.
DR   OrthoDB; 992687at2; -.
DR   PhylomeDB; B2J224; -.
DR   Proteomes; UP000001191; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00524; Glucokinase; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR003836; Glucokinase.
DR   Pfam; PF02685; Glucokinase; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   TIGRFAMs; TIGR00749; glk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..341
FT                   /note="Glucokinase"
FT                   /id="PRO_1000127713"
FT   BINDING         7..12
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00524"
SQ   SEQUENCE   341 AA;  37180 MW;  1E6829F8F4F4873F CRC64;
     MTLLLAGDIG GTKTILQLVE TSDSQGLHTI YQESYHSADF PDLVPIVQQF LIKANTPIPE
     KACFAIAGPI VKNTAKLTNL AWFLDTERLQ QELGIPHIYL INDFAAVGYG ISGLQKQDLH
     PLQVGKPQPE TPIGIIGAGT GLGQGFLIKQ GNNYQVFPSE GGHADFAPRN EIEFQLLKYL
     LDKHDIQRIS VERVVSGMGI VAIYQFLRDR KFAAESPDIA QIVRTWEQEA GQEEKSVDPG
     AAIGTAALEK RDRLSEQTLQ LFIEAYGAEA GNLALKLLPY GGLYIAGGIA PKILPLIQNS
     GFLLNFTQKG RMRPLLEEIP VYIILNPQVG LIGAALCAAR L