ID   GLK_PSEAE               Reviewed;         331 AA.
AC   Q9HZ46;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Glucokinase {ECO:0000255|HAMAP-Rule:MF_00524};
DE            EC=2.7.1.2 {ECO:0000255|HAMAP-Rule:MF_00524};
DE   AltName: Full=Glucose kinase {ECO:0000255|HAMAP-Rule:MF_00524};
GN   Name=glk {ECO:0000255|HAMAP-Rule:MF_00524}; OrderedLocusNames=PA3193;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00524};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00524}.
CC   -!- SIMILARITY: Belongs to the bacterial glucokinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00524}.
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DR   EMBL; AE004091; AAG06581.1; -; Genomic_DNA.
DR   PIR; F83246; F83246.
DR   RefSeq; NP_251883.1; NC_002516.2.
DR   RefSeq; WP_003114838.1; NZ_QZGE01000019.1.
DR   AlphaFoldDB; Q9HZ46; -.
DR   SMR; Q9HZ46; -.
DR   STRING; 287.DR97_4743; -.
DR   PaxDb; Q9HZ46; -.
DR   PRIDE; Q9HZ46; -.
DR   DNASU; 882908; -.
DR   EnsemblBacteria; AAG06581; AAG06581; PA3193.
DR   GeneID; 882908; -.
DR   KEGG; pae:PA3193; -.
DR   PATRIC; fig|208964.12.peg.3339; -.
DR   PseudoCAP; PA3193; -.
DR   HOGENOM; CLU_042582_1_0_6; -.
DR   InParanoid; Q9HZ46; -.
DR   OMA; NNHWRLS; -.
DR   PhylomeDB; Q9HZ46; -.
DR   BioCyc; PAER208964:G1FZ6-3253-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   HAMAP; MF_00524; Glucokinase; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR003836; Glucokinase.
DR   Pfam; PF02685; Glucokinase; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   TIGRFAMs; TIGR00749; glk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..331
FT                   /note="Glucokinase"
FT                   /id="PRO_0000215133"
FT   BINDING         16..21
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00524"
SQ   SEQUENCE   331 AA;  34606 MW;  321718790B5130D1 CRC64;
     MNNDNKRSAG GLGLVGDIGG TNARFALWRG QRLESIEVLA CADYPRPELA VRDYLARIGE
     SVANIDSVCL ACAGPVGAAD FRFTNNHWVI NRAAFREELG LDHLLLVNDF STMAWAASRL
     GADELVQVRA GSAQADRARL IIGPGTGLGV GSLLPLGGGR WEVLPCEGGH VDLPVTSPRD
     FALWQGLQAR YGHVSAERAL SGNGLLALYE ISCALDGVAV RASSAAEVGA LAMAGDAQAD
     AVLEHFFLWL ARVAGNAVLT VGALGGVYIT GGIVPRFLER FIASGFAEAF ASRGKTSGAY
     LQDVPVWVMT AEHPGLLGAG VALQQALDAE G