GLK_RALSO
ID GLK_RALSO Reviewed; 342 AA.
AC P58617;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Glucokinase {ECO:0000255|HAMAP-Rule:MF_00524};
DE EC=2.7.1.2 {ECO:0000255|HAMAP-Rule:MF_00524};
DE AltName: Full=Glucose kinase {ECO:0000255|HAMAP-Rule:MF_00524};
GN Name=glk {ECO:0000255|HAMAP-Rule:MF_00524}; OrderedLocusNames=RSp1557;
GN ORFNames=RS02113;
OS Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OG Plasmid megaplasmid Rsp.
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Ralstonia.
OX NCBI_TaxID=267608;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GMI1000;
RX PubMed=11823852; DOI=10.1038/415497a;
RA Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL Nature 415:497-502(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00524};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00524}.
CC -!- SIMILARITY: Belongs to the bacterial glucokinase family.
CC {ECO:0000255|HAMAP-Rule:MF_00524}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD18708.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL646053; CAD18708.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; P58617; -.
DR SMR; P58617; -.
DR STRING; 267608.RSp1557; -.
DR EnsemblBacteria; CAD18708; CAD18708; RSp1557.
DR KEGG; rso:RSp1557; -.
DR eggNOG; COG0837; Bacteria.
DR HOGENOM; CLU_042582_1_0_4; -.
DR OMA; NNHWRLS; -.
DR Proteomes; UP000001436; Plasmid megaplasmid Rsp.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00524; Glucokinase; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR003836; Glucokinase.
DR Pfam; PF02685; Glucokinase; 1.
DR SUPFAM; SSF53067; SSF53067; 1.
DR TIGRFAMs; TIGR00749; glk; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding; Plasmid;
KW Reference proteome; Transferase.
FT CHAIN 1..342
FT /note="Glucokinase"
FT /id="PRO_0000215134"
FT BINDING 15..20
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00524"
SQ SEQUENCE 342 AA; 35878 MW; 07CB0192479B7C42 CRC64;
MGSMDDVTAY PRLVGDVGGT NARFALEMAP MRLAHIGVLA GDDYPSLEAA MRAYLAALPP
EIAAAGVRHA AIGIANPVLG DQIRMTNRDW AFSTEAMRQS LGFDTFVVLN DFAALAHALP
YLGADELEQV GGSTCVADAP RALLGPGTGL GVASLLPTQA GRFIAVAGEG GHVAFAPMND
EEVVIWRFAR ERFGHVSAER LISGMGLELI YEALGACFDL WQQGPAVRRA ADITAIALGE
MEDTAGDHAR CRYAVDTFCA MLGTVAANLA VTLGARGGVY IGGGIVPRLG AAFANSPFRR
RFEDKGRFSG YVAAMPVYVI HAPYPGLIGL CAAMDHAVAS GH
