ID   GLK_STAXY               Reviewed;         328 AA.
AC   Q56198;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Glucokinase;
DE            EC=2.7.1.2;
DE   AltName: Full=Glucose kinase;
GN   Name=glkA;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=7592379; DOI=10.1128/jb.177.21.6144-6152.1995;
RA   Wagner E., Marcandier S., Egeter O., Deutscher J., Goetz F., Brueckner R.;
RT   "Glucose kinase-dependent catabolite repression in Staphylococcus
RT   xylosus.";
RL   J. Bacteriol. 177:6144-6152(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; X84332; CAA59069.1; -; Genomic_DNA.
DR   PIR; S52352; S52352.
DR   RefSeq; WP_029377187.1; NZ_VEDS01000002.1.
DR   AlphaFoldDB; Q56198; -.
DR   SMR; Q56198; -.
DR   STRING; 1288.SXYLSMQ121_1245; -.
DR   PATRIC; fig|1288.89.peg.400; -.
DR   eggNOG; COG1940; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR004654; ROK_glcA.
DR   PANTHER; PTHR18964; PTHR18964; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   TIGRFAMs; TIGR00744; ROK_glcA_fam; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN           1..328
FT                   /note="Glucokinase"
FT                   /id="PRO_0000095679"
SQ   SEQUENCE   328 AA;  35033 MW;  9BF622D66AF1B5DF CRC64;
     MNKIILAADI GGTTCKLGIF DENLNRLSKW SIDTDTSDTT GYLLLKNIYD SFIQHIDKSD
     NTFSDVLGIG IGVPGPVNFE TGEVNGAVNL YWKGTVNVRD IFKQFVDCPV YVDNDANVAA
     LGEKHKGAGN GADDVVAITL GTGLGGGIIS NGEIVHGHNG SGAEIGHFRV DHDQRFKCNC
     GKSGCIETVA SATGVVNLVN FYYPKLTFKS SILQLIKDNK VSAKAVFDAA KAGDQFCIFI
     TERVANYIAY LCSIVSVTSN PKYIVLGGGM STAGLILIEN IKTEYHNLTF TPAQQNTEIV
     QAQLGNDAGI TGAAGLIYTY IIEKDGVK