ID   GLK_ZYMMO               Reviewed;         324 AA.
AC   P21908; Q5NQL1;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Glucokinase {ECO:0000255|HAMAP-Rule:MF_00524};
DE            EC=2.7.1.2 {ECO:0000255|HAMAP-Rule:MF_00524};
DE   AltName: Full=Glucose kinase {ECO:0000255|HAMAP-Rule:MF_00524};
GN   Name=glk {ECO:0000255|HAMAP-Rule:MF_00524}; OrderedLocusNames=ZMO0369;
OS   Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Zymomonadaceae; Zymomonas.
OX   NCBI_TaxID=264203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=2254282; DOI=10.1128/jb.172.12.7227-7240.1990;
RA   Barnell W.O., Yi K.C., Conway T.;
RT   "Sequence and genetic organization of a Zymomonas mobilis gene cluster that
RT   encodes several enzymes of glucose metabolism.";
RL   J. Bacteriol. 172:7227-7240(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RA   Ahn J.Y., Kang H.S.;
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA   Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA   Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA   Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00524};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00524}.
CC   -!- SIMILARITY: Belongs to the bacterial glucokinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00524}.
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DR   EMBL; M60615; AAA27694.1; -; Genomic_DNA.
DR   EMBL; AF313764; AAG29867.1; -; Genomic_DNA.
DR   EMBL; AE008692; AAV88993.1; -; Genomic_DNA.
DR   PIR; D37855; D37855.
DR   AlphaFoldDB; P21908; -.
DR   SMR; P21908; -.
DR   STRING; 264203.ZMO0369; -.
DR   EnsemblBacteria; AAV88993; AAV88993; ZMO0369.
DR   KEGG; zmo:ZMO0369; -.
DR   eggNOG; COG0837; Bacteria.
DR   HOGENOM; CLU_042582_1_0_5; -.
DR   OMA; GIANRFP; -.
DR   Proteomes; UP000001173; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00524; Glucokinase; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR003836; Glucokinase.
DR   Pfam; PF02685; Glucokinase; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   TIGRFAMs; TIGR00749; glk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..324
FT                   /note="Glucokinase"
FT                   /id="PRO_0000215147"
FT   BINDING         6..11
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00524"
FT   CONFLICT        258
FT                   /note="A -> R (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        313..324
FT                   /note="AAAYANKYSEVE -> QLPMPTNILKLNNIF (in Ref. 1 and 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   324 AA;  34897 MW;  BAAC13AAB6DB8716 CRC64;
     MEIVAIDIGG THARFSIAEV SNGRVLSLGE ETTFKTAEHA SLQLAWERFG EKLGRPLPRA
     AAIAWAGPVH GEVLKLTNNP WVLRPATLNE KLDIDTHVLI NDFGAVAHAV AHMDSSYLDH
     ICGPDEALPS DGVITILGPG TGLGVAHLLR TEGRYFVIET EGGHIDFAPL DRLEDKILAR
     LRERFRRVSI ERIISGPGLG NIYEALAAIE GVPFSLLDDI KLWQMALEGK DNLAEAALDR
     FCLSLGAIAG DLALAQGATS VVIGGGVGLR IASHLPESGF RQRFVSKGRF ERVMSKIPVK
     LITYPQPGLL GAAAAYANKY SEVE