GLL10_CHICK
ID GLL10_CHICK Reviewed; 68 AA.
AC Q6QLQ9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Gallinacin-10;
DE Short=Gal-10;
DE AltName: Full=Beta-defensin 10;
DE AltName: Full=Gallinacin-8;
DE Short=Gal-8;
DE Flags: Precursor;
GN Name=GAL10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in the testis, liver, gall
CC bladder and kidney. Also expressed in the ovary and male and female
CC reproductive tracts. Expressed in the ovarian stroma and the theca and
CC granulosa layers of the ovarian follicle. {ECO:0000269|PubMed:15148642,
CC ECO:0000269|PubMed:15310403, ECO:0000269|PubMed:17244739}.
CC -!- DEVELOPMENTAL STAGE: Detected in the theca and granulosa layers of the
CC ovarian follicle in the white follicle (WF), F1, F3, F5, and
CC postovulatory follicle stages. {ECO:0000269|PubMed:17244739}.
CC -!- INDUCTION: Expression in the theca and granulosa layers of the F3 stage
CC ovarian follicle is not affected by intravenous injection of LPS.
CC {ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY534896; AAS99319.1; -; mRNA.
DR EMBL; AY621312; AAT45550.1; -; mRNA.
DR EMBL; AY621325; AAT48934.1; -; Genomic_DNA.
DR EMBL; DQ677641; ABG73375.1; -; mRNA.
DR EMBL; DQ858307; ABI48222.1; -; mRNA.
DR EMBL; DQ858320; ABI48236.1; -; mRNA.
DR EMBL; DQ858333; ABI48249.1; -; mRNA.
DR EMBL; DQ858347; ABI48263.1; -; mRNA.
DR RefSeq; NP_001001609.1; NM_001001609.1.
DR AlphaFoldDB; Q6QLQ9; -.
DR SMR; Q6QLQ9; -.
DR STRING; 9031.ENSGALP00000026846; -.
DR PaxDb; Q6QLQ9; -.
DR Ensembl; ENSGALT00000026897; ENSGALP00000026846; ENSGALG00000016667.
DR GeneID; 414341; -.
DR KEGG; gga:414341; -.
DR CTD; 414341; -.
DR VEuPathDB; HostDB:geneid_414341; -.
DR eggNOG; ENOG502TDIN; Eukaryota.
DR GeneTree; ENSGT01030000235368; -.
DR HOGENOM; CLU_189296_5_1_1; -.
DR InParanoid; Q6QLQ9; -.
DR OMA; QGNFCRA; -.
DR OrthoDB; 1635261at2759; -.
DR PRO; PR:Q6QLQ9; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000016667; Expressed in kidney and 8 other tissues.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IDA:AgBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:AgBase.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..25
FT /evidence="ECO:0000250"
FT /id="PRO_0000288572"
FT CHAIN 26..68
FT /note="Gallinacin-10"
FT /id="PRO_0000288573"
FT DISULFID 32..61
FT /evidence="ECO:0000250"
FT DISULFID 39..54
FT /evidence="ECO:0000250"
FT DISULFID 44..62
FT /evidence="ECO:0000250"
SQ SEQUENCE 68 AA; 7130 MW; 198C8B462E1F2391 CRC64;
MKILCLLFAV LLFLFQAAPG SADPLFPDTV ACRTQGNFCR AGACPPTFTI SGQCHGGLLN
CCAKIPAQ
