GLL11_CHICK
ID GLL11_CHICK Reviewed; 104 AA.
AC Q6IV20; A0A1W6; Q09MT4; Q9PS49;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Gallinacin-11;
DE Short=Gal-11;
DE AltName: Full=Beta-defensin 11;
DE AltName: Full=Vitelline membrane outer layer protein 2;
DE AltName: Full=Vitelline membrane outer layer protein II;
DE Short=VMO-II;
DE Short=VMOII;
DE Flags: Precursor;
GN Name=GAL11;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ARG-35.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kang X., Jiang R., Han R., Chen Q., Tian Y., Li G.;
RT "Cloning and structure analysis of the Chongren Ma chicken beta-defensin 11
RT (GAL11).";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PROTEIN SEQUENCE OF 23-42, AND TISSUE SPECIFICITY.
RC TISSUE=Egg yolk;
RX PubMed=1520265; DOI=10.1042/bj2860017;
RA Kido S., Morimoto A., Kim F., Doi Y.;
RT "Isolation of a novel protein from the outer layer of the vitelline
RT membrane.";
RL Biochem. J. 286:17-22(1992).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Detected in outer membrane of the vitelline layer
CC of the egg (at protein level). Expressed in the liver, gall bladder,
CC kidney, testis, ovary and male and female reproductive tracts.
CC Expressed in the ovarian stroma, but not in the ovarian follicles. No
CC expression is detected in bone marrow. {ECO:0000269|PubMed:1520265,
CC ECO:0000269|PubMed:15310403, ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY621313; AAT45551.1; -; mRNA.
DR EMBL; AY621326; AAT48935.1; -; Genomic_DNA.
DR EMBL; DQ677642; ABG73376.1; -; mRNA.
DR EMBL; DQ858308; ABI48223.1; -; mRNA.
DR EMBL; DQ858321; ABI48237.1; -; mRNA.
DR EMBL; DQ858334; ABI48250.1; -; mRNA.
DR EMBL; DQ858348; ABI48264.1; -; mRNA.
DR EMBL; DQ997047; ABJ90336.1; -; mRNA.
DR PIR; S23981; S23981.
DR RefSeq; NP_001001779.1; NM_001001779.1.
DR PDB; 6QES; NMR; -; A=23-62.
DR PDB; 6QET; NMR; -; A=63-104.
DR PDB; 6QEU; NMR; -; A=23-104.
DR PDBsum; 6QES; -.
DR PDBsum; 6QET; -.
DR PDBsum; 6QEU; -.
DR AlphaFoldDB; Q6IV20; -.
DR SMR; Q6IV20; -.
DR STRING; 9031.ENSGALP00000030908; -.
DR PaxDb; Q6IV20; -.
DR Ensembl; ENSGALT00000031544; ENSGALP00000030908; ENSGALG00000019846.
DR GeneID; 414876; -.
DR KEGG; gga:414876; -.
DR CTD; 414876; -.
DR VEuPathDB; HostDB:geneid_414876; -.
DR eggNOG; ENOG502R6J6; Eukaryota.
DR GeneTree; ENSGT00530000069149; -.
DR HOGENOM; CLU_2249188_0_0_1; -.
DR InParanoid; Q6IV20; -.
DR OMA; FAAFGTC; -.
DR OrthoDB; 1500248at2759; -.
DR PRO; PR:Q6IV20; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000019846; Expressed in ovary and 1 other tissue.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic; Antimicrobial; Defensin;
KW Direct protein sequencing; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:1520265"
FT CHAIN 23..104
FT /note="Gallinacin-11"
FT /id="PRO_0000288575"
FT DISULFID 30..60
FT /evidence="ECO:0000250"
FT DISULFID 37..53
FT /evidence="ECO:0000250"
FT DISULFID 43..61
FT /evidence="ECO:0000250"
FT VARIANT 35
FT /note="G -> R (in strain: Huiyang bearded)"
FT /evidence="ECO:0000269|Ref.2"
FT CONFLICT 31
FT /note="V -> A (in Ref. 3; ABJ90336)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="H -> L (in Ref. 3; ABJ90336)"
FT /evidence="ECO:0000305"
FT CONFLICT 94
FT /note="P -> H (in Ref. 3; ABJ90336)"
FT /evidence="ECO:0000305"
FT HELIX 27..31
FT /evidence="ECO:0007829|PDB:6QES"
FT STRAND 33..42
FT /evidence="ECO:0007829|PDB:6QES"
FT STRAND 48..51
FT /evidence="ECO:0007829|PDB:6QES"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:6QES"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:6QES"
FT STRAND 65..67
FT /evidence="ECO:0007829|PDB:6QEU"
FT TURN 72..74
FT /evidence="ECO:0007829|PDB:6QET"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:6QET"
FT STRAND 86..89
FT /evidence="ECO:0007829|PDB:6QET"
FT STRAND 94..97
FT /evidence="ECO:0007829|PDB:6QET"
FT STRAND 99..102
FT /evidence="ECO:0007829|PDB:6QET"
SQ SEQUENCE 104 AA; 11650 MW; 1D3E63B15D37F36A CRC64;
MKLFSCLMAL LLFLLQAVPG LGLPRDTSRC VGYHGYCIRS KVCPKPFAAF GTCSWRQKTC
CVDTTSDFHT CQDKGGHCVS PKIRCLEEQL GLCPLKRWTC CKEI
