GLL12_CHICK
ID GLL12_CHICK Reviewed; 65 AA.
AC Q6QLQ7; A0MV42; Q0PWG3; Q6IV19;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Gallinacin-12;
DE Short=Gal-12;
DE AltName: Full=Beta-defensin 12;
DE AltName: Full=Gallinacin-10;
DE Short=Gal-10;
DE Flags: Precursor;
GN Name=GAL12;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Testis;
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ARG-27.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 21-65.
RA Kang X., Jiang R., Li G., Chen H., Sun G., Han R., Chen Q.;
RT "Chicken GAL12 mature peptide fusion protein: gene construction, expression
RT and purification.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the large intestine, kidney liver,
CC gall bladder, testis, ovary and male and female reproductive tracts.
CC Expressed in the ovarian stroma and the theca and granulosa layers of
CC the ovarian follicle. {ECO:0000269|PubMed:15148642,
CC ECO:0000269|PubMed:15310403, ECO:0000269|PubMed:17244739}.
CC -!- DEVELOPMENTAL STAGE: Detected in the theca and granulosa layers of the
CC ovarian follicle in the white follicle (WF), F1, F3, F5, and
CC postovulatory follicle stages. {ECO:0000269|PubMed:17244739}.
CC -!- INDUCTION: Induced in the theca layer of the F3 stage ovarian follicle
CC by intravenous injection of LPS. Repressed in the granulosa layer of
CC the F3 stage ovarian follicle by intravenous injection of LPS.
CC {ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY621314; AAT45552.1; -; mRNA.
DR EMBL; AY621327; AAT48936.1; -; Genomic_DNA.
DR EMBL; AY534898; AAS99321.1; -; mRNA.
DR EMBL; DQ677643; ABG73377.1; -; mRNA.
DR EMBL; DQ858309; ABI48224.1; -; mRNA.
DR EMBL; DQ858322; ABI48238.1; -; mRNA.
DR EMBL; DQ858335; ABI48251.1; -; mRNA.
DR EMBL; DQ858349; ABI48265.1; -; mRNA.
DR EMBL; EF044309; ABK41477.1; -; Genomic_DNA.
DR RefSeq; NP_001001607.2; NM_001001607.2.
DR AlphaFoldDB; Q6QLQ7; -.
DR STRING; 9031.ENSGALP00000030909; -.
DR PaxDb; Q6QLQ7; -.
DR GeneID; 414339; -.
DR KEGG; gga:414339; -.
DR CTD; 414339; -.
DR VEuPathDB; HostDB:geneid_414339; -.
DR eggNOG; ENOG502TD9N; Eukaryota.
DR HOGENOM; CLU_2849122_0_0_1; -.
DR InParanoid; Q6QLQ7; -.
DR OrthoDB; 16317at1549675; -.
DR PRO; PR:Q6QLQ7; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR InterPro; IPR025933; Beta_defensin.
DR Pfam; PF13841; Defensin_beta_2; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..65
FT /note="Gallinacin-12"
FT /id="PRO_0000288576"
FT DISULFID 25..54
FT /evidence="ECO:0000250"
FT DISULFID 32..47
FT /evidence="ECO:0000250"
FT DISULFID 37..55
FT /evidence="ECO:0000250"
FT VARIANT 27
FT /note="H -> R (in strain: Taihe silkies)"
FT /evidence="ECO:0000269|Ref.3"
FT CONFLICT 32
FT /note="C -> S (in Ref. 1; AAT45552)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 65 AA; 7187 MW; 4ED40B65AC77B771 CRC64;
MRNLCFVFIF ISLLAHGSTH GPDSCNHDRG LCRVGNCNPG EYLAKYCFEP VILCCKPLSP
TPTKT
