GLL13_CHICK
ID GLL13_CHICK Reviewed; 89 AA.
AC Q6IV18; Q66VU2;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Gallinacin-13;
DE Short=Gal-13;
DE AltName: Full=Beta-defensin 13;
DE AltName: Full=Gallinacin-11;
DE Short=Gal-11;
DE Flags: Precursor;
GN Name=GAL13;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND TISSUE
RP SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Gall bladder;
RX PubMed=15744537; DOI=10.1007/s00251-005-0777-3;
RA Higgs R., Lynn D.J., Gaines S., McMahon J., Tierney J., James T.,
RA Lloyd A.T., Mulcahy G., O'Farrelly C.;
RT "The synthetic form of a novel chicken beta-defensin identified in silico
RT is predominantly active against intestinal pathogens.";
RL Immunogenetics 57:90-98(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. Potent activity against E.coli,
CC L.monocytogenes, S.typhimurium and S.pyogenes but mot against S.aureus.
CC {ECO:0000269|PubMed:15744537}.
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6IV18-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6IV18-2; Sequence=VSP_025714;
CC -!- TISSUE SPECIFICITY: Expressed in the liver, gall bladder, kidney, small
CC intestine, spleen, testis, ovary and male and female reproductive
CC tracts. Not detected in the ovarian stroma and the theca and granulosa
CC layers of the ovarian follicle. {ECO:0000269|PubMed:15310403,
CC ECO:0000269|PubMed:15744537, ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY621315; AAT45553.1; -; mRNA.
DR EMBL; AY621328; AAT48937.1; -; Genomic_DNA.
DR EMBL; AY701473; AAU07921.1; -; mRNA.
DR EMBL; DQ677644; ABG73378.1; -; mRNA.
DR EMBL; DQ858310; ABI48225.1; -; mRNA.
DR EMBL; DQ858323; ABI48239.1; -; mRNA.
DR EMBL; DQ858336; ABI48252.1; -; mRNA.
DR EMBL; DQ858350; ABI48266.1; -; mRNA.
DR RefSeq; NP_001001780.1; NM_001001780.1. [Q6IV18-1]
DR AlphaFoldDB; Q6IV18; -.
DR SMR; Q6IV18; -.
DR STRING; 9031.ENSGALP00000030910; -.
DR PaxDb; Q6IV18; -.
DR Ensembl; ENSGALT00000031546; ENSGALP00000030910; ENSGALG00000019848. [Q6IV18-1]
DR GeneID; 414877; -.
DR KEGG; gga:414877; -.
DR CTD; 414877; -.
DR VEuPathDB; HostDB:geneid_414877; -.
DR eggNOG; ENOG502TDIW; Eukaryota.
DR GeneTree; ENSGT00940000165539; -.
DR HOGENOM; CLU_189296_0_0_1; -.
DR InParanoid; Q6IV18; -.
DR OMA; MERWEGS; -.
DR OrthoDB; 1632221at2759; -.
DR PRO; PR:Q6IV18; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000019848; Expressed in liver and 6 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:AgBase.
DR GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..89
FT /note="Gallinacin-13"
FT /id="PRO_0000288577"
FT REGION 66..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..58
FT /evidence="ECO:0000250"
FT DISULFID 37..51
FT /evidence="ECO:0000250"
FT DISULFID 41..59
FT /evidence="ECO:0000250"
FT VAR_SEQ 61..89
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15744537, ECO:0000303|Ref.3"
FT /id="VSP_025714"
SQ SEQUENCE 89 AA; 9997 MW; CB1000E95296E558 CRC64;
MRILQLLFAI VVILLLQDAP ARGFSDSQLC RNNHGHCRRL CFHMESWAGS CMNGRLRCCR
FSTKQPFSNP KHSVLHTAEQ DPSPSLGGT
