ID   GLL14_CHICK             Reviewed;          59 AA.
AC   Q0E4V3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Gallinacin-14;
DE            Short=Gal-14;
DE   AltName: Full=Beta-defensin 14;
DE   Flags: Precursor;
GN   Name=GAL14;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Soulier A.J., Rothwell L., Lovell M.A., Bumstead N., Barrow P.A.,
RA   Kaiser P.;
RT   "A novel chicken beta-defensin, gallinacin 14.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM402953; CAL47019.1; -; Genomic_DNA.
DR   EMBL; AM402954; CAL47020.1; -; mRNA.
DR   AlphaFoldDB; Q0E4V3; -.
DR   SMR; Q0E4V3; -.
DR   STRING; 9031.ENSGALP00000042283; -.
DR   VEuPathDB; HostDB:geneid_100858701; -.
DR   eggNOG; ENOG502TBJP; Eukaryota.
DR   HOGENOM; CLU_189296_5_1_1; -.
DR   InParanoid; Q0E4V3; -.
DR   PhylomeDB; Q0E4V3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0002227; P:innate immune response in mucosa; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..59
FT                   /note="Gallinacin-14"
FT                   /id="PRO_0000288578"
FT   DISULFID        25..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   59 AA;  6596 MW;  017B92AB99327761 CRC64;
     MGIFLLFLVL LAVPQAAPES DTVTCRKMKG KCSFLLCPFF KRSSGTCYNG LAKCCRPFW