GLL4_CHICK
ID GLL4_CHICK Reviewed; 63 AA.
AC Q6GXJ1; Q0PXU4; Q6QLR0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Gallinacin-4;
DE Short=Gal-4;
DE AltName: Full=Beta-defensin 4;
DE AltName: Full=Gallinacin-7;
DE Short=Gal-7;
DE Flags: Precursor;
GN Name=GAL4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANT TYR-45, AND TISSUE
RP SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT TYR-45, AND TISSUE SPECIFICITY.
RC TISSUE=Bone marrow;
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT TYR-45.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 26-63.
RC TISSUE=Bone marrow;
RA Kang X., Shi J., Sun G., Han R., Tian Y., Chen Q.;
RT "Cloning and structure analysis of silky fowl beta-defensin gene.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17346671; DOI=10.1016/j.bbrc.2007.02.098;
RA Milona P., Townes C.L., Bevan R.M., Hall J.;
RT "The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial
RT activity against Salmonella serovars.";
RL Biochem. Biophys. Res. Commun. 356:169-174(2007).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. Potent activity against
CC S.typhimurium and S.entiriditis. {ECO:0000269|PubMed:17346671}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in the bone marrow and testis.
CC Widely expressed. Weak expression in the ovarian stroma, but not
CC expressed in the ovarian follicles. {ECO:0000269|PubMed:15148642,
CC ECO:0000269|PubMed:15310403, ECO:0000269|PubMed:17244739,
CC ECO:0000269|PubMed:17346671}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY621306; AAT45544.1; -; mRNA.
DR EMBL; AY621319; AAT48928.1; -; Genomic_DNA.
DR EMBL; AY534895; AAS99318.1; -; mRNA.
DR EMBL; DQ677635; ABG73369.1; -; mRNA.
DR EMBL; DQ858301; ABI48217.1; -; mRNA.
DR EMBL; DQ858314; ABI48230.1; -; mRNA.
DR EMBL; DQ858327; ABI48243.1; -; mRNA.
DR EMBL; DQ858341; ABI48257.1; -; mRNA.
DR EMBL; DQ673442; ABG66308.1; -; mRNA.
DR RefSeq; NP_001001610.1; NM_001001610.2.
DR AlphaFoldDB; Q6GXJ1; -.
DR SMR; Q6GXJ1; -.
DR STRING; 9031.ENSGALP00000035922; -.
DR Ensembl; ENSGALT00000036710; ENSGALP00000035922; ENSGALG00000019843.
DR GeneID; 414342; -.
DR KEGG; gga:414342; -.
DR CTD; 414342; -.
DR VEuPathDB; HostDB:geneid_414342; -.
DR GeneTree; ENSGT01030000235503; -.
DR HOGENOM; CLU_2903560_0_0_1; -.
DR InParanoid; Q6GXJ1; -.
DR OMA; PRHHLRC; -.
DR OrthoDB; 1630105at2759; -.
DR Reactome; R-GGA-1461957; Beta defensins.
DR Reactome; R-GGA-1461973; Defensins.
DR PRO; PR:Q6GXJ1; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000019843; Expressed in granulocyte and 5 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IDA:AgBase.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:AgBase.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..25
FT /evidence="ECO:0000250"
FT /id="PRO_0000288560"
FT CHAIN 26..63
FT /note="Gallinacin-4"
FT /id="PRO_0000288561"
FT DISULFID 31..59
FT /evidence="ECO:0000250"
FT DISULFID 38..53
FT /evidence="ECO:0000250"
FT DISULFID 43..60
FT /evidence="ECO:0000250"
FT VARIANT 45
FT /note="H -> Y (in strain: Guangxi Huang)"
FT /evidence="ECO:0000269|PubMed:15148642,
FT ECO:0000269|PubMed:15310403, ECO:0000269|Ref.3"
SQ SEQUENCE 63 AA; 7163 MW; 7F3FED699F937755 CRC64;
MKILCFFIVL LFVAVHGAVG FSRSPRYHMQ CGYRGTFCTP GKCPHGNAYL GLCRPKYSCC
RWL
