GLL5_CHICK
ID GLL5_CHICK Reviewed; 66 AA.
AC Q6IV26; Q09MS7; Q0PWH0; Q6QLQ8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Gallinacin-5;
DE Short=Gal-5;
DE AltName: Full=Beta-defensin 5;
DE AltName: Full=Gallinacin-9;
DE Short=Gal-9;
DE Flags: Precursor;
GN Name=GAL5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT PRO-5.
RC TISSUE=Tongue;
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS PRO-5; GLY-17; PHE-23 AND ARG-41.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17346671; DOI=10.1016/j.bbrc.2007.02.098;
RA Milona P., Townes C.L., Bevan R.M., Hall J.;
RT "The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial
RT activity against Salmonella serovars.";
RL Biochem. Biophys. Res. Commun. 356:169-174(2007).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250,
CC ECO:0000269|PubMed:17346671}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in the tongue and bone marrow.
CC Low expression in the esophagus, trachea, lung, brain and ovary.
CC Expressed in the ovarian stroma, but not in the ovarian follicles.
CC {ECO:0000269|PubMed:15148642, ECO:0000269|PubMed:15310403,
CC ECO:0000269|PubMed:17244739, ECO:0000269|PubMed:17346671}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY621307; AAT45545.1; -; mRNA.
DR EMBL; AY621320; AAT48929.1; -; Genomic_DNA.
DR EMBL; AY534897; AAS99320.1; -; mRNA.
DR EMBL; DQ677636; ABG73370.1; -; mRNA.
DR EMBL; DQ858302; ABI48218.1; -; mRNA.
DR EMBL; DQ858315; ABI48231.1; -; mRNA.
DR EMBL; DQ858328; ABI48244.1; -; mRNA.
DR EMBL; DQ858342; ABI48258.1; -; mRNA.
DR RefSeq; NP_001001608.2; NM_001001608.2.
DR AlphaFoldDB; Q6IV26; -.
DR PaxDb; Q6IV26; -.
DR Ensembl; ENSGALT00000078421; ENSGALP00000045126; ENSGALG00000042193.
DR GeneID; 414340; -.
DR KEGG; gga:414340; -.
DR CTD; 414340; -.
DR VEuPathDB; HostDB:geneid_414340; -.
DR GeneTree; ENSGT01030000235483; -.
DR InParanoid; Q6IV26; -.
DR OMA; CCRSRWY; -.
DR OrthoDB; 1575691at2759; -.
DR PRO; PR:Q6IV26; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000042193; Expressed in cerebellum and 2 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..25
FT /evidence="ECO:0000250"
FT /id="PRO_0000288562"
FT CHAIN 26..66
FT /note="Gallinacin-5"
FT /id="PRO_0000288563"
FT DISULFID 31..59
FT /evidence="ECO:0000250"
FT DISULFID 38..53
FT /evidence="ECO:0000250"
FT DISULFID 43..60
FT /evidence="ECO:0000250"
FT VARIANT 5
FT /note="T -> P (in strain: Qingyuan Ma)"
FT /evidence="ECO:0000269|PubMed:15148642, ECO:0000269|Ref.3"
FT VARIANT 17
FT /note="A -> G (in strain: Xinghua)"
FT /evidence="ECO:0000269|Ref.3"
FT VARIANT 23
FT /note="L -> F (in strain: Taihe silkies)"
FT /evidence="ECO:0000269|Ref.3"
FT VARIANT 41
FT /note="K -> R (in strain: Taihe silkies)"
FT /evidence="ECO:0000269|Ref.3"
SQ SEQUENCE 66 AA; 7359 MW; 7994273DC25053C9 CRC64;
MQILTLLFAV LLLMLRAEPG LSLARGLPQD CERRGGFCSH KSCPPGIGRI GLCSKEDFCC
RSRWYS
