ID   GLL6_CHICK              Reviewed;          67 AA.
AC   Q6QLR3;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Gallinacin-6;
DE            Short=Gal 6;
DE   AltName: Full=Beta-defensin 6;
DE   AltName: Full=Gallinacin-4;
DE            Short=Gal-4;
DE   Flags: Precursor;
GN   Name=GAL6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Bone marrow;
RX   PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA   Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA   Fares M.A., Mulcahy G., O'Farrelly C.;
RT   "Bioinformatic discovery and initial characterisation of nine novel
RT   antimicrobial peptide genes in the chicken.";
RL   Immunogenetics 56:170-177(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA   Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA   Zhang G.;
RT   "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT   chicken: implications for the origin and evolution of mammalian
RT   defensins.";
RL   BMC Genomics 5:56-56(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC   Xinghua;
RA   Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT   "Chicken beta-defensin in China chicken breeds.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=17346671; DOI=10.1016/j.bbrc.2007.02.098;
RA   Milona P., Townes C.L., Bevan R.M., Hall J.;
RT   "The chicken host peptides, gallinacins 4, 7, and 9 have antimicrobial
RT   activity against Salmonella serovars.";
RL   Biochem. Biophys. Res. Commun. 356:169-174(2007).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=17244739; DOI=10.1530/rep-06-0083;
RA   Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT   "Changes in the expression of gallinacins, antimicrobial peptides, in
RT   ovarian follicles during follicular growth and in response to
RT   lipopolysaccharide in laying hens (Gallus domesticus).";
RL   Reproduction 133:127-133(2007).
CC   -!- FUNCTION: Has bactericidal activity. Potent activity against
CC       S.typhimurium and S.entiriditis. {ECO:0000269|PubMed:17346671}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in bone marrow, testis, ovary, lung and
CC       trachea. Expressed in the ovarian stroma, but not in the ovarian
CC       follicles. {ECO:0000269|PubMed:15148642, ECO:0000269|PubMed:15310403,
CC       ECO:0000269|PubMed:17244739, ECO:0000269|PubMed:17346671}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AY534892; AAS99315.1; -; mRNA.
DR   EMBL; AY621308; AAT45546.1; -; mRNA.
DR   EMBL; AY621321; AAT48930.1; -; Genomic_DNA.
DR   EMBL; DQ677637; ABG73371.1; -; mRNA.
DR   EMBL; DQ858303; ABI48219.1; -; mRNA.
DR   EMBL; DQ858316; ABI48232.1; -; mRNA.
DR   EMBL; DQ858329; ABI48245.1; -; mRNA.
DR   EMBL; DQ858343; ABI48259.1; -; mRNA.
DR   RefSeq; NP_001001193.1; NM_001001193.1.
DR   AlphaFoldDB; Q6QLR3; -.
DR   SMR; Q6QLR3; -.
DR   STRING; 9031.ENSGALP00000026847; -.
DR   PaxDb; Q6QLR3; -.
DR   Ensembl; ENSGALT00000026898; ENSGALP00000026847; ENSGALG00000016668.
DR   GeneID; 407776; -.
DR   KEGG; gga:407776; -.
DR   CTD; 407776; -.
DR   VEuPathDB; HostDB:geneid_407776; -.
DR   GeneTree; ENSGT00420000030710; -.
DR   HOGENOM; CLU_189296_5_0_1; -.
DR   OMA; YYRVGSC; -.
DR   OrthoDB; 1584343at2759; -.
DR   PhylomeDB; Q6QLR3; -.
DR   Reactome; R-GGA-1461957; Beta defensins.
DR   Reactome; R-GGA-1461973; Defensins.
DR   PRO; PR:Q6QLR3; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000016668; Expressed in granulocyte and 4 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..25
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000288564"
FT   CHAIN           26..67
FT                   /note="Gallinacin-6"
FT                   /id="PRO_0000288565"
FT   DISULFID        31..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..61
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  7554 MW;  87BDD4EBD2AAB595 CRC64;
     MRILYLLLSV LFVVLQGVAG QPYFSSPIHA CRYQRGVCIP GPCRWPYYRV GSCGSGLKSC
     CVRNRWA