GLL7_CHICK
ID GLL7_CHICK Reviewed; 67 AA.
AC Q6QLR2; Q09MR1; Q09MV1;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Gallinacin-7;
DE Short=Gal 7;
DE AltName: Full=Beta-defensin 7;
DE AltName: Full=Gallinacin-5;
DE Short=Gal-5;
DE Flags: Precursor;
GN Name=GAL7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Bone marrow;
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS PHE-9 AND PHE-33.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in the bone marrow and testis.
CC Expressed in the ovarian stroma and the theca layer of the ovarian
CC follicles. Not expressed in the granulosa layer of the ovarian
CC follicles. {ECO:0000269|PubMed:15148642, ECO:0000269|PubMed:15310403,
CC ECO:0000269|PubMed:17244739}.
CC -!- DEVELOPMENTAL STAGE: Detected in the theca and granulosa layers of the
CC ovarian follicle in the white follicle (WF), F1, F3, F5, and
CC postovulatory follicle stages. {ECO:0000269|PubMed:17244739}.
CC -!- INDUCTION: Induced in the theca layer of the F3 stage ovarian follicle
CC by intravenous injection of LPS. Expression in the kidney and liver is
CC not affected by intravenous injection of LPS.
CC {ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY534893; AAS99316.1; -; mRNA.
DR EMBL; AY621309; AAT45547.1; -; mRNA.
DR EMBL; AY621322; AAT48931.1; -; Genomic_DNA.
DR EMBL; DQ677638; ABG73372.1; -; mRNA.
DR EMBL; DQ858304; ABI48220.1; -; mRNA.
DR EMBL; DQ858317; ABI48233.1; -; mRNA.
DR EMBL; DQ858330; ABI48246.1; -; mRNA.
DR EMBL; DQ858344; ABI48260.1; -; mRNA.
DR RefSeq; NP_001001194.1; NM_001001194.1.
DR PDB; 5LCS; NMR; -; A=22-67.
DR PDBsum; 5LCS; -.
DR AlphaFoldDB; Q6QLR2; -.
DR SMR; Q6QLR2; -.
DR STRING; 9031.ENSGALP00000030905; -.
DR PaxDb; Q6QLR2; -.
DR Ensembl; ENSGALT00000031541; ENSGALP00000030905; ENSGALG00000047285.
DR GeneID; 407777; -.
DR KEGG; gga:407777; -.
DR CTD; 407777; -.
DR VEuPathDB; HostDB:geneid_407777; -.
DR eggNOG; ENOG502TD9D; Eukaryota.
DR GeneTree; ENSGT00420000030710; -.
DR HOGENOM; CLU_189296_5_0_1; -.
DR InParanoid; Q6QLR2; -.
DR OMA; WIGTCNN; -.
DR OrthoDB; 1632233at2759; -.
DR PhylomeDB; Q6QLR2; -.
DR Reactome; R-GGA-1461957; Beta defensins.
DR Reactome; R-GGA-1461973; Defensins.
DR PRO; PR:Q6QLR2; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000047285; Expressed in granulocyte and 6 other tissues.
DR ExpressionAtlas; Q6QLR2; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..25
FT /evidence="ECO:0000250"
FT /id="PRO_0000288566"
FT CHAIN 26..67
FT /note="Gallinacin-7"
FT /id="PRO_0000288567"
FT DISULFID 31..60
FT /evidence="ECO:0000250"
FT DISULFID 38..53
FT /evidence="ECO:0000250"
FT DISULFID 43..61
FT /evidence="ECO:0000250"
FT VARIANT 9
FT /note="S -> F (in strain: Qingyuan Ma)"
FT /evidence="ECO:0000269|Ref.3"
FT VARIANT 33
FT /note="L -> F (in strain: Guangxi Huang)"
FT /evidence="ECO:0000269|Ref.3"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:5LCS"
FT STRAND 45..53
FT /evidence="ECO:0007829|PDB:5LCS"
FT HELIX 54..56
FT /evidence="ECO:0007829|PDB:5LCS"
FT STRAND 58..64
FT /evidence="ECO:0007829|PDB:5LCS"
SQ SEQUENCE 67 AA; 7563 MW; EDA1C64AB3EEF368 CRC64;
MRILYLLLSV LFVVLQGVAG QPFIPRPIDT CRLRNGICFP GICRRPYYWI GTCNNGIGSC
CARGWRS
