GLL8_CHICK
ID GLL8_CHICK Reviewed; 66 AA.
AC Q6IV23; Q6GXI7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Gallinacin-8;
DE Short=Gal 8;
DE AltName: Full=Beta-defensin 8;
DE AltName: Full=Gallinacin-12;
DE Short=Gal-12;
DE Flags: Precursor;
GN Name=GAL8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Gall bladder;
RX PubMed=15744537; DOI=10.1007/s00251-005-0777-3;
RA Higgs R., Lynn D.J., Gaines S., McMahon J., Tierney J., James T.,
RA Lloyd A.T., Mulcahy G., O'Farrelly C.;
RT "The synthetic form of a novel chicken beta-defensin identified in silico
RT is predominantly active against intestinal pathogens.";
RL Immunogenetics 57:90-98(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in the liver, kidney, gall bladder,
CC testis, ovary and male and femae reproductive tracts. Expressed in the
CC ovarian stroma and the theca and granulosa layers of the ovarian
CC follicle. {ECO:0000269|PubMed:15310403, ECO:0000269|PubMed:15744537,
CC ECO:0000269|PubMed:17244739}.
CC -!- DEVELOPMENTAL STAGE: Detected in the theca and granulosa layers of the
CC ovarian follicle in the white follicle (WF), F1, F3, F5, and
CC postovulatory follicle stages. {ECO:0000269|PubMed:17244739}.
CC -!- INDUCTION: Induced in the theca layer of the F3 stage ovarian follicle
CC by intravenous injection of LPS. Expression in the granulosa layer of
CC the ovarian follicle is not affected by intravenous injection of LPS.
CC {ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY621310; AAT45548.1; -; mRNA.
DR EMBL; AY621323; AAT48932.1; -; Genomic_DNA.
DR EMBL; AY701474; AAU07922.1; -; mRNA.
DR EMBL; DQ677639; ABG73373.1; -; mRNA.
DR EMBL; DQ858305; ABI48221.1; -; mRNA.
DR EMBL; DQ858318; ABI48234.1; -; mRNA.
DR EMBL; DQ858331; ABI48247.1; -; mRNA.
DR EMBL; DQ858345; ABI48261.1; -; mRNA.
DR RefSeq; NP_001001781.1; NM_001001781.1.
DR AlphaFoldDB; Q6IV23; -.
DR STRING; 9031.ENSGALP00000035929; -.
DR PaxDb; Q6IV23; -.
DR GeneID; 414875; -.
DR KEGG; gga:414875; -.
DR CTD; 414875; -.
DR VEuPathDB; HostDB:geneid_414875; -.
DR eggNOG; ENOG502TD9I; Eukaryota.
DR HOGENOM; CLU_189296_3_0_1; -.
DR InParanoid; Q6IV23; -.
DR PRO; PR:Q6IV23; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..25
FT /evidence="ECO:0000250"
FT /id="PRO_0000288568"
FT CHAIN 26..66
FT /note="Gallinacin-8"
FT /id="PRO_0000288569"
FT DISULFID 31..60
FT /evidence="ECO:0000250"
FT DISULFID 38..54
FT /evidence="ECO:0000250"
FT DISULFID 43..61
FT /evidence="ECO:0000250"
FT CONFLICT 6
FT /note="L -> F (in Ref. 1; AAT48932)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 66 AA; 7395 MW; DA5D33C34AC96A08 CRC64;
MKILYLLLAV LLTVLQSSLG FMRVPNNEAQ CEQAGGICSK DHCFHLHTRA FGHCQRGVPC
CRTVYD
