GLL9_CHICK
ID GLL9_CHICK Reviewed; 67 AA.
AC Q6QLR1; Q09MS3;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Gallinacin-9;
DE Short=Gal-9;
DE AltName: Full=Beta-defensin 9;
DE AltName: Full=Gallinacin-6;
DE Short=Gal-6;
DE Flags: Precursor;
GN Name=GAL9;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-2.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17194828; DOI=10.1128/aac.00568-06;
RA van Dijk A., Veldhuizen E.J.A., Kalkhove S.I.C.,
RA Tjeerdsma-van Bokhoven J.L.M., Romijn R.A., Haagsman H.P.;
RT "The beta-defensin gallinacin-6 is expressed in the chicken digestive tract
RT and has antimicrobial activity against food-borne pathogens.";
RL Antimicrob. Agents Chemother. 51:912-922(2007).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. Potent activity against C.jejuni,
CC C.perfringens, S.aureus, C.albicans and S.cerevisiae. Less potent
CC against S.typhimurium and E.coli. {ECO:0000269|PubMed:17194828}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in the testis, liver, gall
CC bladder, kidney, esophagus and crop. Also expressed in the glandular
CC stomach, ovary and male and female reproductive tracts. Low expression
CC in the intestinal tract. Expressed in the ovarian stroma, but not in
CC the ovarian follicles. {ECO:0000269|PubMed:15148642,
CC ECO:0000269|PubMed:15310403, ECO:0000269|PubMed:17194828,
CC ECO:0000269|PubMed:17244739}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AY534894; AAS99317.1; -; mRNA.
DR EMBL; AY621311; AAT45549.1; -; mRNA.
DR EMBL; AY621324; AAT48933.1; -; Genomic_DNA.
DR EMBL; DQ677640; ABG73374.1; -; mRNA.
DR EMBL; DQ858306; ABI48226.1; -; mRNA.
DR EMBL; DQ858319; ABI48235.1; -; mRNA.
DR EMBL; DQ858332; ABI48248.1; -; mRNA.
DR EMBL; DQ858346; ABI48262.1; -; mRNA.
DR RefSeq; NP_001001611.1; NM_001001611.2.
DR AlphaFoldDB; Q6QLR1; -.
DR SMR; Q6QLR1; -.
DR STRING; 9031.ENSGALP00000035930; -.
DR PaxDb; Q6QLR1; -.
DR Ensembl; ENSGALT00000036719; ENSGALP00000035930; ENSGALG00000019845.
DR GeneID; 414343; -.
DR KEGG; gga:414343; -.
DR CTD; 414343; -.
DR VEuPathDB; HostDB:geneid_414343; -.
DR eggNOG; ENOG502TDI6; Eukaryota.
DR GeneTree; ENSGT00960000187509; -.
DR HOGENOM; CLU_189296_5_1_1; -.
DR InParanoid; Q6QLR1; -.
DR OMA; RQNRGSC; -.
DR OrthoDB; 1618911at2759; -.
DR Reactome; R-GGA-1461957; Beta defensins.
DR Reactome; R-GGA-1461973; Defensins.
DR PRO; PR:Q6QLR1; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000019845; Expressed in liver and 6 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:AgBase.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Fungicide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..25
FT /evidence="ECO:0000250"
FT /id="PRO_0000288570"
FT CHAIN 26..67
FT /note="Gallinacin-9"
FT /id="PRO_0000288571"
FT DISULFID 31..60
FT /evidence="ECO:0000250"
FT DISULFID 38..53
FT /evidence="ECO:0000250"
FT DISULFID 43..61
FT /evidence="ECO:0000250"
FT VARIANT 2
FT /note="R -> G (in strain: Xinghua)"
FT /evidence="ECO:0000269|Ref.3"
SQ SEQUENCE 67 AA; 7279 MW; D7692A291B83F0F1 CRC64;
MRILFFLVAV LFFLFQAAPA YSQEDADTLA CRQSHGSCSF VACRAPSVDI GTCRGGKLKC
CKWAPSS
