ID   GLMK_PREBR              Reviewed;          25 AA.
AC   P82680;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Glucomannokinase;
DE   Includes:
DE     RecName: Full=Glucokinase;
DE              EC=2.7.1.2;
DE   Includes:
DE     RecName: Full=Mannokinase;
DE              EC=2.7.1.7;
DE   Flags: Fragment;
OS   Prevotella bryantii.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=77095;
RN   [1]
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   STRAIN=B14;
RX   PubMed=11283299; DOI=10.1099/00221287-147-4-1035;
RA   Fields M.W., Russell J.B.;
RT   "The glucomannokinase of Prevotella bryantii B14 and its potential role in
RT   regulating beta-glucanase expression.";
RL   Microbiology 147:1035-1043(2001).
CC   -!- FUNCTION: The enzyme has great affinity for glucose and mannose.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-mannose = ADP + D-mannose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:11028, ChEBI:CHEBI:4208, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58735, ChEBI:CHEBI:456216; EC=2.7.1.7;
CC   -!- ACTIVITY REGULATION: Competitively inhibited by 2-deoxy-glucose.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC       phosphate and glycerone phosphate from D-glucose: step 1/4.
CC   -!- PATHWAY: Carbohydrate metabolism; mannose metabolism.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   AlphaFoldDB; P82680; -.
DR   SMR; P82680; -.
DR   UniPathway; UPA00109; UER00180.
DR   UniPathway; UPA00339; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019158; F:mannokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:UniProtKB-UniPathway.
PE   1: Evidence at protein level;
KW   ATP-binding; Direct protein sequencing; Glycolysis; Kinase;
KW   Multifunctional enzyme; Nucleotide-binding; Transferase.
FT   CHAIN           1..>25
FT                   /note="Glucomannokinase"
FT                   /id="PRO_0000095680"
FT   NON_TER         25
SQ   SEQUENCE   25 AA;  2670 MW;  3D56E14510A22558 CRC64;
     MNEQSMKPYV IGLDLGGTNS VFGIV